Evidence map›Paper›PMID 33619882›Full record

ArticleJournal of cellular and molecular medicine2021

Depressed β-adrenergic inotropic responsiveness and intracellular calcium handling abnormalities in Duchenne Muscular Dystrophy patients' induced pluripotent stem cell-derived cardiomyocytes.

Lucy N Mekies, Danielle Regev, Binyamin Eisen, Jonatan Fernandez-Gracia, Polina Baskin, Ronen Ben Jehuda, Rita Shulman, Irina Reiter, Raz Palty, Michael Arad and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

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  8. InvestigatingInternational journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Lucy N MekiesDepartment of Physiology, Biophysics and Systems Biology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Danielle RegevDepartment of Physiology, Biophysics and Systems Biology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Binyamin EisenDepartment of Physiology, Biophysics and Systems Biology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.ORCID 0000-0002-2185-5054
Jonatan Fernandez-GraciaDepartment of Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Polina BaskinDepartment of Physiology, Biophysics and Systems Biology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Ronen Ben JehudaDepartment of Physiology, Biophysics and Systems Biology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Rita ShulmanDepartment of Physiology, Biophysics and Systems Biology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Irina ReiterDepartment of Physiology, Biophysics and Systems Biology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Raz PaltyDepartment of Biochemistry, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Michael AradLeviev Heart Center, Sheba Medical Center, Ramat Gan, Israel.
Eyal GottliebDepartment of Cell Biology and Cancer Science, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.
Ofer BinahDepartment of Physiology, Biophysics and Systems Biology, Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.ORCID 0000-0001-6567-1903
Technion – Israel Institute of Technology · ILTel Aviv University · IL

Funding

Israel Science Foundation (ISF) 824/19Niedersachsen Foundation ZN3452The Rappaport Foundation grant 01012020RIThe US-Israel Binational Science Foundation (BSF) 2019039
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD), caused by mutations in the dystrophin gene, is an X-linked disease affecting male and rarely adult heterozygous females, resulting in death by the late 20s to early 30s. Previous studies reported depressed left ventricular function in DMD patients which may result from deranged intracellular Ca

Indexed as

Gene Expression RegulationMyocardial ContractionAdrenergic AgentsAdultCalciumCalcium Channels, L-TypeCell DifferentiationFemaleHumansInduced Pluripotent Stem CellsMaleMiddle AgedMuscular Dystrophy, DuchenneMyocytes, CardiacReceptors, Adrenergic, beta-1RNA-SeqADRB1 protein, humanAdrenergic AgentsCalciumCalcium Channels, L-TypeReceptors, Adrenergic, beta-1[Ca2+]i transientscontractionsduchenne muscular dystrophyinduced pluripotent stem cell-derived cardiomyocytesRNA-sequencingSR Ca2+ storesβ-adrenergic responsiveness

Identifiers

PMID33619882
PMCPMC8051742
OpenAlexW3133267572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.