Evidence map›Paper›PMID 33619876›Full record

ArticleOrthopaedic surgery2021

Protection of Icariin Against Hydrogen Peroxide-Induced MC3T3-E1 Cell Oxidative Damage.

Jian-Bin Sun, Zheng Wang, Wei-Jun An

Open access · goldAbstract read
In one paragraph

Article in Orthopaedic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jian-Bin SunDepartment of Trauma Orthopaedics, The General Hospital of Ningxia Medical University, Yinchuan, China.ORCID https://orcid.org/0000-0002-5048-1493
Zheng WangDepartment of Trauma Orthopaedics, The General Hospital of Ningxia Medical University, Yinchuan, China.
Wei-Jun AnDepartment of Trauma Orthopaedics, The General Hospital of Ningxia Medical University, Yinchuan, China.
Ningxia Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of the present study was to evaluate the potential protective mechanism of icariin against oxidative damage caused by hydrogen peroxide in MC3T3-E1 cells.

methodsMC3T3-E1 cells were treated with different concentrations of icariin to explore the optimal dose of icariin. MC3T3-E1 cells were divided into groups treated with various concentrations of hydrogen peroxide (H

resultsAfter 24 h of exposure to 0.2 mM H

conclusionThe results showed that icariin can increase the viability of MC3T3-E1 cells, reverse the oxidative stress induced by H

Indexed as

AnimalsCell DifferentiationCell LineCell SurvivalDrugs, Chinese HerbalFlavonoidsHydrogen PeroxideMiceOsteoblastsOxidative StressWnt Signaling PathwayDrugs, Chinese HerbalFlavonoidsHydrogen PeroxideicariinH2O2IcariinMC3T3-E1Osteogenesis

Identifiers

PMID33619876
PMCPMC7957425
OpenAlexW3131003460

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.