Evidence map›Paper›PMID 33619853›Full record

ArticleJournal of the International AIDS Society2021

Estimating HIV incidence in the Akwa Ibom AIDS indicator survey (AKAIS), Nigeria using the limiting antigen avidity recency assay.

Olubunmi R Negedu-Momoh, Oluseyi Balogun, Ibrahim Dafa, Akan Etuk, Edward Adekola Oladele, Oluwasanmi Adedokun, Ezekiel James, Satish R Pandey, Hadiza Khamofu, Titi Badru and 3 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the International AIDS Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

Olubunmi R Negedu-MomohLaboratory services and HSS Department, FHI 360, Abuja, Nigeria.ORCID 0000-0003-3347-8177
Oluseyi BalogunLaboratory services and HSS Department, FHI 360, Abuja, Nigeria.
Ibrahim DafaLaboratory services and HSS Department, FHI 360, Abuja, Nigeria.
Akan EtukLaboratory Services Department, University of Uyo Teaching Hospital, Uyo, Nigeria.
Edward Adekola OladelePrevention, Care and Treatment Department, FHI 360, Abuja, Nigeria.ORCID 0000-0003-4999-1397
Oluwasanmi AdedokunMonitoring and Evaluation Department, FHI 360, Abuja, Nigeria.
Ezekiel JamesOffice of the HIV/AIDS and TB, United States Agency for International Development (USAID), Abuja, Nigeria.
Satish R PandeyProgram Management Department, FHI 360, Abuja, Nigeria.
Hadiza KhamofuPrevention, Care and Treatment Department, FHI 360, Abuja, Nigeria.
Titi BadruMonitoring and Evaluation Department, FHI 360, Abuja, Nigeria.
Janet RobinsonInfectious Diseases and Health Systems, FHI 360, Durham, NC, USA.
Timothy D MastroFHI 360, Durham, NC, USA.
Kwasi TorpeyCollege of Health Sciences, University of Ghana, Accra, Ghana.
Family Health International 360 · USCenter for Clinical Care and Research in Nigeria · NGUnited States Agency for International Development · USUniversity of Ghana · GHUniversity of Uyo Teaching Hospital · NG

Funding

PEPFAR
6 · The paper itself

Abstract

introductionHIV incidence estimates are important to characterize the status of an epidemic, identify locations and populations at high risk and to guide and evaluate HIV prevention interventions. We used the limiting antigen avidity assay (LAg) as part of a recent infection testing algorithm to estimate HIV incidence in the Akwa Ibom AIDS Indicator Survey (AKAIS), Nigeria.

methodsIn 2017, AKAIS, a cross-sectional population-based study was conducted at the household (HH) level in 31 local government areas (LGAs) of Akwa Ibom state. Of the 8963 participants aged ≥15 years who were administered questionnaires for demographic and behavioural data, 8306 consented to HIV rapid testing. Whole-blood specimens were collected from 394 preliminary HIV-seropositive individuals for CD4+ cell count determination and plasma storage. Samples were shipped to a central quality laboratory for HIV confirmatory testing and viral load determination. A total of 370 HIV-positive specimens were tested for the recent HIV infection using the LAg assay.

resultsOf the 8306 consenting adults, the HIV prevalence was 4.8%. Of the 370 HIV-positive samples tested for HIV recency, the median age was 35 years, 48.8% had CD4+ cell count >500/mm

conclusionsThe finding of the high HIV incidence among the 15 to 49-year age group calls for renewed and innovative efforts to prevent HIV infection among young adults in Akwa Ibom state.

Indexed as

AdolescentAdultAntibody AffinityAnti-HIV AgentsCross-Sectional StudiesFemaleHIV-1HIV AntibodiesHIV AntigensHIV InfectionsHIV SeropositivityHumansImmunoenzyme TechniquesIncidenceInfant, NewbornMaleAnti-HIV AgentsHIV AntibodiesHIV AntigensHIV-1incidencelimiting antigen avidityNigeriarecent infectionviral load

Identifiers

PMID33619853
PMCPMC7900440
OpenAlexW3131205590

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.