ReviewDrugs & aging2021
Seizures and Epilepsy After Stroke: Epidemiology, Biomarkers and Management.
Review in Drugs & aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
90 citing papers in PubMed, 2 syntheses or guidelines pooled it, 176 citations in OpenAlex.
- Antiseizure Medications in Poststroke Seizures: A Systematic Review and Network Meta-Analysis.Neurology · 2025Pooled it
- A bibliometric analysis of electroencephalogram research in stroke: current trends and future directions.Frontiers in neurology · 2025Pooled it
- Association of circulating miR-210 with post-stroke seizures and clinical outcome: A preliminary study.IBRO neuroscience reports · 2026Article
- Systemic inflammatory profiles associated with early EEG abnormalities following ischemic stroke: a cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Observational
- Continuous Versus Short EEG After Ischemic Stroke: What cEEG Adds for Detecting Abnormalities and Predicting Post-Stroke Epilepsy.Annals of neurology · 2026Article
- Post-Stroke Epileptogenesis as a Dynamic Network Process: State-Dependent Biomarkers, Longitudinal Monitoring, and the Concept of an Irritable Brain State.International journal of molecular sciences · 2026Review
- Nonlinear Association Between the C-Reactive Protein-To-Albumin Ratio and Post-Stroke Epilepsy Risk.CNS neuroscience & therapeutics · 2026Article
- Association of carotid revascularization with epilepsy and seizures in patients with carotid stenosis.Epilepsia · 2026Article
- Post-stroke epilepsy in Saudi Arabia - frequency, management and outcomes at a comprehensive stroke center in Riyadh, Kingdom of Saudi Arabia.BMC neurology · 2026Article
- Intravenous human umbilical cord-derived mesenchymal stem cell transplantation for ischemic stroke (MERIT): A phase 1 trial.Cell reports. Medicine · 2026Article
- From Cortex to Context: Rethinking Late-Onset Epilepsy Risk.Epilepsy currents · 2026Article
- Targeting Hsp90 with cemdomespib reduces seizure burden and alters disease course in preclinical epilepsy models.Epilepsia · 2026Article
- The incidence and impact of early post-stroke seizures for successful endovascular stroke treatment: an individual patient data level analysis of trials.International journal of surgery (London, England) · 2026Article
- Anti-seizure medications in patients with post-stroke epilepsy: A survival analysis study.Epilepsia · 2026Article
- Inflammatory-neurological deficit versus metabolic dysregulation: unsupervised clustering and SHAP analysis.Frontiers in immunology · 2026Article
- Electroencephalography in stroke Care: From acute monitoring to Post-Stroke epilepsy.Clinical neurophysiology practice · 2026Review
- Synergistic impact of immuno-nutritional and hypoxia-metabolic disturbances on post-stroke epilepsy: a "Two-Hit" prediction model and web-based risk calculator.Frontiers in nutrition · 2026Article
- A Comparative Study of Seizure in Elderly Male and Female Patients Pertaining to Etiology, Radiological Features, and Electroencephalographic Findings.Annals of African medicine · 2026Observational
- Angiographic signs during mechanical thrombectomy as predictors of post-stroke epilepsy: a multicenter retrospective study.Journal of neurointerventional surgery · 2025Article
- Aperiodic Activity Reflects Pathologic Waveform Shapes in Focal Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 7 institutions in 8 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke is the leading cause of seizures and epilepsy in older adults. Patients who have larger and more severe strokes involving the cortex, are younger, and have acute symptomatic seizures and intracerebral haemorrhage are at highest risk of developing post-stroke epilepsy. Prognostic models, including the SeLECT and CAVE scores, help gauge the risk of epileptogenesis. Early electroencephalogram and blood-based biomarkers can provide information additional to the clinical risk factors of post-stroke epilepsy. The management of acute versus remote symptomatic seizures after stroke is markedly different. The choice of an ideal antiseizure medication should not only rely on efficacy but also consider adverse effects, altered pharmacodynamics in older adults, and the influence on the underlying vascular co-morbidity. Drug-drug interactions, particularly those between antiseizure medications and anticoagulants or antiplatelets, also influence treatment decisions. In this review, we describe the epidemiology, risk factors, biomarkers, and management of seizures after an ischaemic or haemorrhagic stroke. We discuss the special considerations required for the treatment of post-stroke epilepsy due to the age, co-morbidities, co-medication, and vulnerability of stroke survivors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.