ArticleJournal of assisted reproduction and genetics2021
Improved maturation competence of ovarian tissue oocytes using a biphasic in vitro maturation system for patients with gynecological malignancy: a study on sibling oocytes.
Article in Journal of assisted reproduction and genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Twenty-first century oocyte cryopreservation-in vitro maturation of immature oocytes from ovarian tissue cryopreservation in cancer patients: A systematic review.Women's health (London, England)Pooled it
- Advances in the application of assisted reproductive technology in fertility preservation for female patients with malignant tumours of the reproductive systems.Annals of medicine · 2026Review
- The use of ex-vivo in-vitro maturation of ovarian tissues oocytes (OTO-IVM) for fertility preservation in gynaecologic cancers.Gynecologic oncology reports · 2026Article
- Ovarian tissue oocyte-in vitro maturation combined with ovarian tissue cryopreservation: a promising urgent fertility preservation strategy for hematological patients before HSCT.Journal of ovarian research · 2026Article
- Advances, Mechanisms, and Clinical Perspectives for the In Vitro Maturation of Human Oocytes.International journal of molecular sciences · 2025Review
- Advances in human oocyte in vitro maturation: current status and future perspectives: a narrative review.Reproduction & fertility · 2025Review
- Biphasic CAPA-IVM Improves Equine Oocyte Quality and Subsequent Embryo Development Without Inducing Genetic Aberrations.International journal of molecular sciences · 2025Article
- Current status and hotspots of in vitro oocyte maturation: a bibliometric study of the past two decades.Journal of assisted reproduction and genetics · 2025Review
- Quality of IVM ovarian tissue oocytes: impact of clinical, demographic, and laboratory factors.Journal of assisted reproduction and genetics · 2024Article
- New Insights on In Vitro Maturation of Oocytes for Fertility Preservation.International journal of molecular sciences · 2024Review
- Pronuclear transfer rescues poor embryo development ofHuman reproduction open · 2024Article
- In vitro maturation (IVM) of human immature oocytes: is it still relevant?Reproductive biology and endocrinology : RB&E · 2023Review
- Cumulative live birth rate after oocyte in vitro maturation with a pre-maturation step in women with polycystic ovary syndrome or high antral follicle count.Journal of assisted reproduction and genetics · 2023Article
- A synopsis of global frontiers in fertility preservation.Journal of assisted reproduction and genetics · 2022Review
- High efficiency of homemade culture medium supplemented with GDF9-β in human oocytes for rescue in vitro maturation.Clinical and experimental reproductive medicine · 2022Article
- Effect of cumulin and super-GDF9 in standard and biphasic mouse IVM.Journal of assisted reproduction and genetics · 2022Article
- Factors Influencing the In Vitro Maturation (IVM) of Human Oocyte.Biomedicines · 2021Review
- In Vitro Maturation of Oocytes Retrieved from Ovarian Tissue: Outcomes from Current Approaches and Future Perspectives.Journal of clinical medicine · 2021Review
- The Role of Mitochondria in Oocyte Maturation.Cells · 2021Review
- Perspectives on the development and future of oocyte IVM in clinical practice.Journal of assisted reproduction and genetics · 2021Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo investigate the developmental competence of ovarian tissue oocytes from patients with gynecological tumors using a biphasic in vitro maturation system with capacitation (CAPA-IVM) in comparison with standard IVM.
methodsThis sibling pilot study included 210 oocytes in 10 patients with gynecological malignancies. After ovariectomies, ovaries were cut into even halves and immature cumulus-oocyte complexes (COCs) were retrieved from the ovarian tissue. COCs were separately cultured in either a biphasic CAPA-IVM system for 53 h or in standard IVM for 48 h. After IVM, all COCs were denuded and mature oocytes were either vitrified (N=5) or used for ICSI (N=5). Embryos were cultured for 5-6 days and obtained blastocysts were vitrified.
resultsUse of the CAPA-IVM system led to a higher meiotic maturation rate in ovarian tissue oocytes (OTO) compared to standard IVM (56 vs 35%, p=0.0045) and had a tendency to result in lower degeneration after IVM. Only the CAPA-IVM method supported blastocyst formation.
conclusionsThe biphasic in vitro maturation system improved the competence of OTO in comparison to the standard IVM method. The study suggests that fertility preservation programs could become more efficient using IVM after capacitation culture.
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