Evidence map›Paper›PMID 33619614›Full record

ReviewCellular and molecular life sciences : CMLS2021

Links between mitochondrial retrograde response and mitophagy in pathogenic cell signalling.

Daniela Strobbe, Soumya Sharma, Michelangelo Campanella

Open access · bronzeAbstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Mitochondrial metabolism and cancer therapeutic innovation.Signal transduction and targeted therapy · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. Mitochondrial sites of contact with the nucleus.The Journal of cell biology · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Daniela StrobbeDepartment of Biology, University of Rome "Tor Vergata", 00133, Rome, Italy.
Soumya SharmaDepartment of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London, NW10TU, UK.
Michelangelo CampanellaDepartment of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, Royal College Street, London, NW10TU, UK. mcampanella@rvc.ac.uk.
Royal Veterinary College · GBUniversity College London · GBUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preservation of mitochondrial quality is paramount for cellular homeostasis. The integrity of mitochondria is guarded by the balanced interplay between anabolic and catabolic mechanisms. The removal of bio-energetically flawed mitochondria is mediated by the process of mitophagy; the impairment of which leads to the accumulation of defective mitochondria which signal the activation of compensatory mechanisms to the nucleus. This process is known as the mitochondrial retrograde response (MRR) and is enacted by Reactive Oxygen Species (ROS), Calcium (Ca

Indexed as

MitophagySignal TransductionAdenosine TriphosphateAnimalsCalciumHumansLipid MetabolismMitochondriaNeoplasmsProteostasisReactive Oxygen SpeciesAdenosine TriphosphateCalciumReactive Oxygen SpeciesCell signalling and CancerMitochondrial retrograde responseMitophagy

Identifiers

PMID33619614
PMCPMC11071702
OpenAlexW3131830646

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.