Evidence map›Paper›PMID 33619501›Full record

ArticlemedRxiv : the preprint server for health sciences2021

Genome-wide analysis in 756,646 individuals provides first genetic evidence that

J E Horowitz, J A Kosmicki, A Damask, D Sharma, G H L Roberts, A E Justice, N Banerjee, M V Coignet, A Yadav, J B Leader and 50 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

60 authors at 3 institutions in 1 country.

J E Horowitz *Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
J A Kosmicki *Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
A Damask *Regeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
D SharmaRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
G H L RobertsAncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
A E JusticeGeisinger, Danville, PA, 17822, USA.
N BanerjeeRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
M V CoignetAncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
A YadavRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
J B LeaderGeisinger, Danville, PA, 17822, USA.
A MarckettaRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
D S ParkAncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
R LancheRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
E MaxwellRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
S C KnightAncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
X BaiRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
H GuturuAncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
D SunRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
A BaltzellAncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
F S P KuryRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
J D BackmanRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
A R GirshickAncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
C O'DushlaineRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
S R McCurdyAncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
R ParthaAncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
A J MansfieldRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
D A TurissiniAncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
A H LiRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
M ZhangAncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
J MbatchouRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
K WatanabeRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
L GurskiRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
S E McCarthyRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
H M KangRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
L DobbynRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
E StahlRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
A VermaDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
G SirugoDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Regeneron Genetics Center
M D RitchieDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
M JonesRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
S BalasubramanianRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
K SiminovitchRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
W J SalernoRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
A R ShuldinerRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
D J RaderDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
T MirshahiGeisinger, Danville, PA, 17822, USA.
A E LockeRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
J MarchiniRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
J D OvertonRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
D J CareyGeisinger, Danville, PA, 17822, USA.
L HabeggerRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
M N CantorRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
K A RandAncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
E L HongAncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
J G ReidRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
C A BallAncestryDNA, 1300 West Traverse Parkway, Lehi, UT 84043, USA.
A BarasRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
G R AbecasisRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
M A FerreiraRegeneron Genetics Center, 777 Old Saw Mill River Rd., Tarrytown, NY 10591, USA.
Regeneron (United States) · USGeisinger Medical Center · USUniversity of Pennsylvania · US

Funding

Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4M
NCATS NIH HHS UL1 TR001878
6 · The paper itself

Abstract

SARS-CoV-2 enters host cells by binding angiotensin-converting enzyme 2 (ACE2). Through a genome-wide association study, we show that a rare variant (MAF = 0.3%, odds ratio 0.60,

Identifiers

PMID33619501
PMCPMC7899471
OpenAlexW3112994972

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.