Evidence map›Paper›PMID 33619497›Full record

ArticlemedRxiv : the preprint server for health sciences2021

SARS-CoV-2 Seroprevalence in a University Community: A Longitudinal Study of the Impact of Student Return to Campus on Infection Risk Among Community Members.

Callum R K Arnold, Sreenidhi Srinivasan, Sophie Rodriguez, Natalie Rydzak, Catherine M Herzog, Abhinay Gontu, Nita Bharti, Meg Small, Connie J Rogers, Margeaux M Schade and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 16 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Callum R K ArnoldDepartment of Biology, Pennsylvania State University, University Park, PA, USA 16802.
Sreenidhi SrinivasanCenter for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA, USA 16802.
Sophie RodriguezHuck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA 16802.
Natalie RydzakDepartment of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, USA 16802.
Catherine M HerzogCenter for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA, USA 16802.
Abhinay GontuDepartment of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA, USA 16802.
Nita BhartiDepartment of Biology, Pennsylvania State University, University Park, PA, USA 16802.
Meg SmallCollege of Health and Human Development, Pennsylvania State University, University Park, PA, USA 16802.
Connie J RogersDepartment of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA 16802.
Margeaux M SchadeSocial Science Research Institute, Pennsylvania State University, University Park, PA, USA 16802.
Suresh V KuchipudiCenter for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA, USA 16802.
Vivek KapurCenter for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA, USA 16802.
Andrew ReadDepartment of Biology, Pennsylvania State University, University Park, PA, USA 16802.
Matthew J FerrariDepartment of Biology, Pennsylvania State University, University Park, PA, USA 16802.
Pennsylvania State University · US

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
NCATS NIH HHS UL1 TR002014
6 · The paper itself

Abstract

backgroundReturning university students represent large-scale, transient demographic shifts and a potential source of transmission to adjacent communities during the COVID-19 pandemic.

methodsIn this prospective longitudinal cohort study, we tested for IgG antibodies against SARS-CoV-2 in a non-random cohort of residents living in Centre County prior to the Fall 2020 term at the Pennsylvania State University and following the conclusion of the Fall 2020 term. We also report the seroprevalence in a non-random cohort of students collected at the end of the Fall 2020 term.

resultsOf 1313 community participants, 42 (3.2%) were positive for SARS-CoV-2 IgG antibodies at their first visit between 07 August and 02 October 2020. Of 684 student participants who returned to campus for fall instruction, 208 (30.4%) were positive for SARS-CoV-2 antibodies between 26 October and 21 December. 96 (7.3%) community participants returned a positive IgG antibody result by 19 February. Only contact with known SARS-CoV-2-positive individuals and attendance at small gatherings (20-50 individuals) were significant predictors of detecting IgG antibodies among returning students (aOR, 95% CI: 3.1, 2.07-4.64; 1.52, 1.03-2.24; respectively).

conclusionsDespite high seroprevalence observed within the student population, seroprevalence in a longitudinal cohort of community residents was low and stable from before student arrival for the Fall 2020 term to after student departure. The study implies that heterogeneity in SARS-CoV-2 transmission can occur in geographically coincident populations.

Indexed as

COVID-19SARS-CoV-2Seroprevalence

Identifiers

PMID33619497
PMCPMC7899462
OpenAlexW3131106745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.