Evidence map›Paper›PMID 33619478›Full record

ArticlebioRxiv : the preprint server for biology2021

The Host Interactome of Spike Expands the Tropism of SARS-CoV-2.

Casimir Bamberger, Sandra Pankow, Salvador Martínez-Bartolomé, Jolene Diedrich, Robin Park, John Yates

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 13 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Casimir BambergerDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Sandra PankowDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Salvador Martínez-BartoloméDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Jolene DiedrichDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Robin ParkDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
John YatesDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Scripps Research Institute · US

Funding

TrainingP41GM103533 · NIGMS · UNIVERSITY OF WASHINGTON · PI MACCOSS, MICHAEL · 2012 to 2021
$20.7M
Measurement of Aberrant Protein Folds in Malignant Cells with Proteomics and Mass SpectrometryR33CA212973 · NCI · SCRIPPS RESEARCH INSTITUTE, THE · PI YATES III, JOHN R · 2017 to 2019
$1.2M
NCI NIH HHS R33 CA212973NIGMS NIH HHS P41 GM103533
6 · The paper itself

Abstract

The SARS-CoV-2 virus causes severe acute respiratory syndrome (COVID-19) and has rapidly created a global pandemic. Patients that survive may face a slow recovery with long lasting side effects that can afflict different organs. SARS-CoV-2 primarily infects epithelial airway cells that express the host entry receptor Angiotensin Converting Enzyme 2 (ACE2) which binds to spike protein trimers on the surface of SARS-CoV-2 virions. However, SARS-CoV-2 can spread to other tissues even though they are negative for ACE2. To gain insight into the molecular constituents that might influence SARS-CoV-2 tropism, we determined which additional host factors engage with the viral spike protein in disease-relevant human bronchial epithelial cells (16HBEo

Indexed as

astrocytesbiochemical reaction networksbioinformatic analysis of proteomesbottom up mass spectrometrybrain tissuecell ontologycellular microbiologyCoPITcoronavirusdendritic cellsemerging spike variantsextracellular matrixfibroblastsmast cellsmegakaryocytesmonocytesmuscleoligodendrocytesprotein foldingprotein quality controlproteome analysisSARS-CoV-2 strainsstructural biology modelingunfolded protein responsevirus host interactionsvirus replicationvirus variants

Identifiers

PMID33619478
PMCPMC7899442
OpenAlexW3130155688

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.