ArticleNature neuroscience2021
Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex.
Article in Nature neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 77 citations in OpenAlex.
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- Cooperative actions of interneuron families support the hippocampal spatial code.Science (New York, N.Y.) · 2025Article
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- Integrating endocannabinoid signaling, CCK interneurons, and hippocampal circuit dynamics in behaving animals.Neuron · 2025Review
- A Distinct Down-to-Up Transition Assembly in the Retrosplenial Cortex during Slow-Wave Sleep.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Mechanistic insights into the interaction between epilepsy and sleep.Nature reviews. Neurology · 2025Review
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- The human claustrum tracks slow waves during sleep.Nature communications · 2024Article
- A hippocampal circuit mechanism to balance memory reactivation during sleep.Science (New York, N.Y.) · 2024Article
- Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation.Nature communications · 2024Article
- Prefrontal cortical ripples mediate top-down suppression of hippocampal reactivation during sleep memory consolidation.Current biology : CB · 2024Article
- Neurogliaform Cells Exhibit Laminar-specific Responses in the Visual Cortex and Modulate Behavioral State-dependent Cortical Activity.Research square · 2024Article
- Neurogliaform Cells Exhibit Laminar-specific Responses in the Visual Cortex and Modulate Behavioral State-dependent Cortical Activity.bioRxiv : the preprint server for biology · 2024Article
- Spontaneous persistent activity and inactivity in vivo reveals differential cortico-entorhinal functional connectivity.Nature communications · 2024Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Pyramidal cells and GABAergic interneurons fire together in balanced cortical networks. In contrast to this general rule, we describe a distinct neuron type in mice and rats whose spiking activity is anti-correlated with all principal cells and interneurons in all brain states but, most prevalently, during the down state of non-REM (NREM) sleep. We identify these down state-active (DSA) neurons as deep-layer neocortical neurogliaform cells that express ID2 and Nkx2.1 and are weakly immunoreactive to neuronal nitric oxide synthase. DSA neurons are weakly excited by deep-layer pyramidal cells and strongly inhibited by several other GABAergic cell types. Spiking of DSA neurons modified the sequential firing order of other neurons at down-up transitions. Optogenetic activation of ID2
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Registered trials
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