ArticleNature metabolism2021
A unique subset of glycolytic tumour-propagating cells drives squamous cell carcinoma.
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Article in Nature metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
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Who cites it
29 citing papers in PubMed, 46 citations in OpenAlex.
- Review
- Histone methylation defines c-Jun/Sox2/Hif1α axis that controls stemness and tumor progression in squamous cell carcinoma.Nature communications · 2026Article
- Ability of lactylation-related genes to stratify patients with ovarian cancer and predict immunotherapy response.Translational cancer research · 2026Article
- ETS1 Promotes Aerobic Glycolysis and Growth in Head and Neck Squamous Cell Carcinoma by Targeting RRAS2.Biochemical genetics · 2025Article
- SIRT6 in Cancer: Mechanistic Insights into Its Dual Roles in Cancer Biology and Implications for Precision Therapeutic Development.Biomolecules · 2025Review
- KDM6A phosphorylation suppresses PER2 to confer a glycolytic vulnerability in HNSCC.Cell death & disease · 2025Article
- Pharmacological activation of SIRT6 suppresses progression of head and neck and esophageal squamous cell carcinoma by modulation of cellular metabolism and protein translation.Cell death & disease · 2025Article
- Article
- A new method to measure cell metabolism of rare cells in vivo reveals a high oxidative phosphorylation dependence of lung T cells.Immunology and cell biology · 2025Article
- Regulation of Stem Cell Function by NADPhysiology (Bethesda, Md.) · 2025Review
- Nutrient transporter-oriented nanoinhibitor counteracts intracellular metabolic reprogramming for RT-resistant HCC treatment.Materials today. Bio · 2025Article
- Suppressing SENP1 inhibits esophageal squamous carcinoma cell growth via SIRT6 SUMOylation.Cellular oncology (Dordrecht, Netherlands) · 2025Article
- Saikosaponin D Mitigates Radioresistance in Triple-Negative Breast Cancer by Inducing MRE11 De-Lactylation via HIF1α/HDAC5 Pathway.Theranostics · 2025Article
- Lactate in skin homeostasis: metabolism, skin barrier, and immunomodulation.Frontiers in immunology · 2025Review
- Dichloroacetate for Cancer Treatment: Some Facts and Many Doubts.Pharmaceuticals (Basel, Switzerland) · 2024Review
- The glutathione S-transferase Gstt1 drives survival and dissemination in metastases.Nature cell biology · 2024Article
- Histone lactylation: from tumor lactate metabolism to epigenetic regulation.International journal of biological sciences · 2024Review
- Interplay between epigenetics and metabolism controls cancer stem cell plasticity.Frontiers in epigenetics and epigenomics · 2024Review
- Triosephosphate isomerase 1 may be a risk predictor in laryngeal squamous cell carcinoma: a multi-centered study integrating bulk RNA, single-cell RNA, and protein immunohistochemistry.European journal of medical research · 2023Article
- Integrative lactylation and tumor microenvironment signature as prognostic and therapeutic biomarkers in skin cutaneous melanoma.Journal of cancer research and clinical oncology · 2023Article
Corrections and comments
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Authors and funding
24 authors at 7 institutions in 4 countries.
Jee-Eun ChoiThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Carlos SebastianThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Christina M FerrerThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Caroline A LewisThe Whitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1787-5084
Moshe Sade-FeldmanThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Thomas LaSalleThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8390-6072
Anna GonyeThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0034-1756
Begona G C LopezDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Walid M AbdelmoulaDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3117-7389
Michael S ReganDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Murat CetinbasDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Gloria PascualInstitute for Research and Biomedicine (IRB) Barcelona, The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID http://orcid.org/0000-0003-3810-6647
Gregory R WojtkiewiczCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3148-8411
Giorgia G SilveiraThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1798-0191
Ruben BoonThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9355-674X
Kenneth N RossThe Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Itay TiroshDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0001-5477-2987
Srinivas V SaladiThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Leif W EllisenThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0444-7910
Ruslan I SadreyevDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Salvador Aznar BenitahInstitute for Research and Biomedicine (IRB) Barcelona, The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.ORCID http://orcid.org/0000-0002-9059-5049
Nathalie Y R AgarDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nir HacohenThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2349-2656
Raul MostoslavskyThe Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA. rmostoslavsky@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-7740-5212
Harvard University · USBroad Institute · USBrigham and Women's Hospital · USInstitució Catalana de Recerca i Estudis Avançats · ESMassachusetts Eye and Ear Infirmary · USWeizmann Institute of Science · ILWhitehead Institute for Biomedical Research · US
Funding
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6MP63 mediators as therapeutic targets in HNSCCR01DE015945 · NIDCR · MASSACHUSETTS GENERAL HOSPITAL · PI ELLISEN, LEIF W · 2004 to 2021
$6.9MMechanistic Understanding for the Role of Lin28b in Pancreatic Cancer ProgressionR01CA235412 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI EL-BARDEESY, NABEEL, MOSTOSLAVSKY, RAUL · 2019 to 2023
$3.2MThe Role of SIRT6 and Metabolism in APC Mediated TumorigenesisR01CA175727 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MOSTOSLAVSKY, GUSTAVO, MOSTOSLAVSKY, RAUL · 2014 to 2018
$2.6MThe histone deacetylase SIRT6 modulates Transcriptional pausingR01GM128448 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI MOSTOSLAVSKY, RAUL · 2019 to 2022
$1.6MHistone tails as an energy reservoir for mitochondrial functionR33ES025638 · NIEHS · MASSACHUSETTS GENERAL HOSPITAL · PI MOSTOSLAVSKY, RAUL · 2018 to 2019
$821kEffects of Communicating RPFNA Results on Decisions about Tamoxifen UseR21CA120342 · NCI · DUKE UNIVERSITY · PI LIPKUS, ISAAC M · 2007 to 2008
$328kNCI NIH HHS R01 CA175727NCI NIH HHS R01 CA235412NCI NIH HHS R21 CA120342NIDDK NIH HHS P30 DK040561NIEHS NIH HHS R33 ES025638NIGMS NIH HHS R01 GM128448
Abstract
Head and neck squamous cell carcinoma (SCC) remains among the most aggressive human cancers. Tumour progression and aggressiveness in SCC are largely driven by tumour-propagating cells (TPCs). Aerobic glycolysis, also known as the Warburg effect, is a characteristic of many cancers; however, whether this adaptation is functionally important in SCC, and at which stage, remains poorly understood. Here, we show that the NAD
Indexed as
GlycolysisAnimalsAntioxidantsDisease ProgressionGlutathioneHead and Neck NeoplasmsHumansMiceMice, Inbred C57BLMice, KnockoutNeoplastic Stem CellsPentose Phosphate PathwayRNA, NeoplasmSingle-Cell AnalysisSirtuinsSquamous Cell Carcinoma of Head and NeckAntioxidantsGlutathioneRNA, NeoplasmSIRT6 protein, humanSirt6 protein, mouseSirtuins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.