Evidence map›Paper›PMID 33619202›Full record

Trial reportBMJ open2021

Does cranberry extract reduce antibiotic use for symptoms of acute uncomplicated urinary tract infections (CUTI)? A feasibility randomised trial.

Oghenekome Gbinigie, Julie Allen, Nicola Williams, Michael Moore, Alastair D Hay, Carl Heneghan, Anne-Marie Boylan, Christopher C Butler

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Cranberries for treating urinary tract infections.The Cochrane database of systematic reviews · 2023
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Non-antibiotic treatment of acute urinary tract infection in primary care: a qualitative study.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Oghenekome GbinigieNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK oghenekome.gbinigie@phc.ox.ac.uk.ORCID 0000-0002-2963-4491
Julie AllenNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Nicola WilliamsNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Michael MoorePrimary Care Medical Group, University of Southampton Medical School, Southampton, UK.ORCID 0000-0002-5127-4509
Alastair D HayCentre for Academic Primary Care, University of Bristol, Bristol, UK.
Carl HeneghanNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.ORCID 0000-0002-1009-1992
Anne-Marie BoylanNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.ORCID 0000-0001-8187-0742
Christopher C ButlerNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.ORCID 0000-0002-0102-3453

Funding

Wellcome TrustWellcome Trust 203921
6 · The paper itself

Abstract

objectivesTo determine the feasibility of conducting a randomised trial of the effectiveness of cranberry extract in reducing antibiotic use by women with symptoms of acute, uncomplicated urinary tract infection (UTI).

designOpen-label feasibility randomised parallel group trial.

settingFour general practices in Oxfordshire.

participantsWomen aged 18 years and above presenting to general practice with symptoms of acute, uncomplicated UTI.

interventionsWomen were randomly assigned using Research Electronic Data Capture in a 1:1:1 ratio to: (1) immediate antibiotics alone (n=15); (2) immediate antibiotics and immediate cranberry capsules for up to 7 days (n=15); or (3) immediate cranberry capsules and delayed antibiotics for self-initiation in case of non-improvement or worsening of symptoms (n=16). PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome measures were: rate of recruitment of participants; numbers lost to follow-up; proportion of electronic diaries completed by participants; and acceptability of the intervention and study procedures to participants and recruiters. Secondary outcomes included an exploration of differences in symptom burden and antibiotic use between groups.

resultsFour general practitioner practices (100%) were opened and recruited participants between 1 July and 2 December 2019, with nine study participants recruited per month on average. 68.7% (46/67) of eligible participants were randomised (target 45) with a mean age of 48.4 years (SD 19.9, range 18-81). 89.1% (41/46) of diaries contained some participant entered data and 69.6% (32/46) were fully complete. Three participants (6.5%) were lost to follow-up and two (4.4%) withdrew. Of women randomly assigned to take antibiotics alone (controls), one-third of respondents reported consuming cranberry products (33.3%, 4/12). There were no serious adverse events.

conclusionsIt appears feasible to conduct a randomised trial of the use of cranberry extract in the treatment of acute, uncomplicated UTI in general practice. TRIAL REGISTRATION NUMBER: ISRCTN Registry (ID: 10399299).

Indexed as

Urinary Tract InfectionsVaccinium macrocarponAdolescentAnti-Bacterial AgentsFeasibility StudiesFemaleHumansMiddle AgedPlant ExtractsAnti-Bacterial AgentsPlant Extractsclinical trialsprimary careurinary tract infections

Identifiers

PMID33619202
PMCPMC7903114

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.