Evidence map›Paper›PMID 33619128›Full record

ArticleBritish journal of sports medicine2022

Regular exercise and patterns of response across multiple cardiometabolic traits: the HERITAGE family study.

Jacob L Barber, Jonathan J Ruiz-Ramie, Jeremy M Robbins, Robert E Gerszten, Arthur S Leon, D C Rao, James S Skinner, Claude Bouchard, Mark A Sarzynski

Abstract read
In one paragraph

Article in British journal of sports medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Genes · 2025
    Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Stubborn Exercise Responders-Where to Next?Sports (Basel, Switzerland) · 2022
    Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jacob L BarberDepartment of Exercise Science, University of South Carolina, Columbia, South Carolina, USA.ORCID http://orcid.org/0000-0002-8132-1601
Jonathan J Ruiz-RamieDepartment of Exercise Science, University of South Carolina, Columbia, South Carolina, USA.
Jeremy M RobbinsBeth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Robert E GersztenBeth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Arthur S LeonSchool of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA.
D C RaoDivision of Biostatistics, Washington University School of Medicine in Saint Louis, Saint Louis, Missouri, USA.
James S SkinnerDepartment of Kinesiology, Indiana University Bloomington, Bloomington, Indiana, USA.
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA.ORCID http://orcid.org/0000-0002-0048-491X
Mark A SarzynskiDepartment of Exercise Science, University of South Carolina, Columbia, South Carolina, USA sarz@mailbox.sc.edu.

Funding

HERITAGE STUDY: GENETICS, EXERCISE &RISK FACTORSR01HL045670 · NHLBI · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI RANKINEN, TUOMO · 1992 to 2010
$6.8M
Molecular Basis of Exercise-induced Changes in HDL FunctionR01HL146462 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SARZYNSKI, MARK ANDREW · 2019 to 2023
$3.6M
HERITAGE STUDY: GENETICS, EXERCISE &RISK FACTORSR01HL047317 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 1992 to 2003
$1.8M
DMGV and the AGXT2 pathway in chronic exercise-induced cardiometabolic adaptations.K23HL150327 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROBBINS, JEREMY · 2020 to 2024
$850k
HERITAGE STUDY: GENETICS, EXERCISE &RISK FACTORSR01HL047327 · NHLBI · INDIANA UNIVERSITY BLOOMINGTON · PI SKINNER, JAMES STANFORD · 1992 to 2003
$106k
HERITAGE STUDY: GENETICS, RESP. TO EXERCISE/RISK FACTORSR01HL047323 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LEON, ARTHUR S · 1992 to 2003
$100k
NHLBI NIH HHS K23 HL150327NHLBI NIH HHS R01 HL045670NHLBI NIH HHS R01 HL047317NHLBI NIH HHS R01 HL047323NHLBI NIH HHS R01 HL047327NHLBI NIH HHS R01 HL146462
6 · The paper itself

Abstract

objectivesWe investigated whether high responsiveness or low responsiveness to exercise training aggregates in the same individuals across seven cardiometabolic traits.

methodsA total of 564 adults (29.2% black, 53.7% female) from the HERITAGE family study completed a 20-week endurance training programme (at 55%-75% of participants' maximal oxygen uptake (VO

resultsOnly one individual had universally high or low responses for all seven cardiometabolic traits. Almost half (49%) of the cohort had at least one high response and one low response across the seven traits. About 24% had at least one high response but no low responses, 24% had one or more low responses but no high responses, and 2.5% had average responses across all traits.

conclusionsInterindividual variation in exercise responses was evident in all the traits we investigated, and responsiveness did not aggregate consistently in the same individuals. While adherence to an exercise prescription is known to produce health benefits, targeted risk factors may not improve.

Indexed as

Cardiovascular DiseasesExerciseHeart Disease Risk FactorsAdipose TissueAdultCholesterol, HDLFemaleHumansMaleOxygen ConsumptionCholesterol, HDLexercise physiologyexercise training

Identifiers

PMID33619128
PMCPMC8380259

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.