Evidence map›Paper›PMID 33619062›Full record

ArticleAntimicrobial agents and chemotherapy2023

Developing synergistic drug combinations to restore antibiotic sensitivity in drug-resistant

Charles Omollo, Vinayak Singh, Elizabeth Kigondu, Antonina Wasuna, Pooja Agarwal, Atica Moosa, Thomas R Ioerger, Valerie Mizrahi, Kelly Chibale, Digby F Warner

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Menaquinone depletion resensitises bedaquiline-resistant tuberculosis.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Netupitant Exhibits Potent Activity onACS infectious diseases · 2025
    Article
  7. Antimicrobial efficiency of bromhexine hydrochloride against endometritis-causing Escherichia coli and Trueperella pyogenes in bovines.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Article
  8. Article
  9. Article
  10. Unlocking Opportunities forACS infectious diseases · 2024
    Review
  11. Review
  12. Article
  13. In vitro model to simulate multiple drugs with distinct elimination half-lives.International journal of antimicrobial agents · 2023
    Article
  14. The human proton pump inhibitors inhibitProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Review
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Charles OmolloDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa charles.omollo@uct.ac.za digby.warner@uct.ac.za.
Vinayak SinghDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.ORCID https://orcid.org/0000-0001-9002-2489
Elizabeth KigonduDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
Antonina WasunaDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
Pooja AgarwalSAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DSI/NRF Centre of Excellence for Biomedical Tuberculosis Research, Department of Pathology, University of Cape Town, Rondebosch 7701, South Africa.
Atica MoosaSAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DSI/NRF Centre of Excellence for Biomedical Tuberculosis Research, Department of Pathology, University of Cape Town, Rondebosch 7701, South Africa.
Thomas R IoergerTexas A&M University, Department of Computer Science, College Station, TX, 77843, USA.
Valerie MizrahiSAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DSI/NRF Centre of Excellence for Biomedical Tuberculosis Research, Department of Pathology, University of Cape Town, Rondebosch 7701, South Africa.
Kelly ChibaleDepartment of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
Digby F WarnerSAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DSI/NRF Centre of Excellence for Biomedical Tuberculosis Research, Department of Pathology, University of Cape Town, Rondebosch 7701, South Africa charles.omollo@uct.ac.za digby.warner@uct.ac.za.ORCID https://orcid.org/0000-0002-4146-0930
South African Medical Research Council · ZATexas A&M University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis (TB) is a leading global cause of mortality owing to an infectious agent, accounting for almost one-third of antimicrobial resistance (AMR) deaths annually. We aimed to identify synergistic anti-TB drug combinations with the capacity to restore therapeutic efficacy against drug-resistant mutants of the causative agent,

Identifiers

PMID33619062
PMCPMC8092878
OpenAlexW3129318754

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.