Evidence map›Paper›PMID 33619051›Full record

ArticleThe British journal of general practice : the journal of the Royal College of General Practitioners2021

Guidance impact on primary care prescribing rates of simple analgesia: an interrupted time series analysis in England.

Hannah Reichel, Rhian Stanbrook, Hans Johnson, William Proto, Mary Shantikumar, Pooja Bakhshi, Sarah Hillman, Dan Todkill, Saran Shantikumar

Abstract read
In one paragraph

Article in The British journal of general practice : the journal of the Royal College of General Practitioners, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Sociodemographic disparities in primary care management of back pain in children and young people: a population-based cohort study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hannah ReichelWarwick Medical School, University of Warwick, Coventry.
Rhian StanbrookMedwyn Surgery, Surrey.
Hans JohnsonBristol Medical School, University of Bristol, Bristol.
William ProtoWarwick Medical School, University of Warwick, Coventry.
Mary ShantikumarCentral Surgery, Rugby.
Pooja BakhshiRegistrar in paediatrics, Health Education West Midlands, Birmingham.
Sarah HillmanWarwick Medical School, University of Warwick, Coventry.ORCID 0000-0002-3560-2074
Dan TodkillWarwick Medical School, University of Warwick, Coventry.
Saran ShantikumarWarwick Medical School, University of Warwick, Coventry.ORCID 0000-0002-8565-5385

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn March 2018, NHS England published guidance for clinical commissioning groups (CCGs) to encourage implementation of policy to reduce primary care prescriptions of over-the-counter medications, including simple analgesia.

aimTo investigate the impact of guidance publication on prescribing rates of simple analgesia (oral paracetamol, oral ibuprofen, and topical non-steroidal anti-inflammatory drugs) in primary care; CCG guidance implementation intentions; and whether the guidance has created health inequality based on socioeconomic status. DESIGN AND

settingInterrupted time series analysis of primary care prescribing data in England.

methodPractice-level prescribing data from January 2015 to March 2019 were obtained from NHS Digital. Interrupted time series analyses were used to assess the association of guidance publication with prescribing rates. The association between practice-level prescribing rates and Index of Multiple Deprivation scores before and after publication was quantified using multivariable Poisson regression. Freedom of information requests were submitted to all CCGs.

resultsThere was a statistically significant 4.4% reduction in prescribing of simple analgesia following guidance publication (adjusted incidence rate ratio 0.96, 95% CI = 0.92 to 0.99,

conclusionGuidance publication was associated with a small reduction in the prescribing rates of simple analgesia across England, without evidence of creating additional health inequality. Careful implementation by CCGs would be required to optimise cost saving to the NHS.

Indexed as

AnalgesiaHealth Status DisparitiesEnglandHumansInterrupted Time Series AnalysisPractice Patterns, Physicians'Primary Health Careanalgesiageneral practiceinterrupted time series analysisprescriptions

Identifiers

PMID33619051
PMCPMC7906621

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.