Evidence map›Paper›PMID 33619044›Full record

Trial reportPediatrics2021

Extended Work Shifts and Neurobehavioral Performance in Resident-Physicians.

Shadab A Rahman, Jason P Sullivan, Laura K Barger, Melissa A St Hilaire, Conor S O'Brien, Katie L Stone, Andrew J K Phillips, Elizabeth B Klerman, Salim Qadri, Kenneth P Wright and 13 more

Open access · greenAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Impact of shift durations on sleep, fatigue, and wellness among neonatologists: a cross-sectional survey analysis.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  6. Article
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  8. Observational
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Article
  14. Review
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  17. Review
  18. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 14 institutions in 3 countries.

Shadab A RahmanDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts; sarahman@rics.bwh.harvard.edu.
Jason P SullivanDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts.
Laura K BargerDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts.
Melissa A St HilaireDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts.
Conor S O'BrienDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts.
Katie L StoneCalifornia Pacific Medical Center Research Institute, San Francisco, California.
Andrew J K PhillipsDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts.
Elizabeth B KlermanDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts.
Salim QadriDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts.
Kenneth P WrightSleep and Chronobiology Laboratory, Department of Integrative Physiology, University of Colorado Boulder, Boulder, Colorado.
Ann C HalbowerDepartment of Pediatrics, Children's Hospital Colorado and School of Medicine, University of Colorado, Aurora, Colorado.
Jeffrey L SegarUniversity of Iowa Stead Family Children's Hospital, Iowa City, Iowa.
John K McGuireSeattle Children's Hospital, Seattle, Washington.
Michael V VitielloDepartments of Psychiatry and Behavioral Sciences, and.
Horacio O de la IglesiaBiology, University of Washington, Seattle, Washington.
Sue E PoynterDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati, Cincinnati, Ohio.
Pearl L YuUniversity of Virginia Children's Hospital, Charlottesville, Virginia.
Amy L SandersonDivision of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine and.
Phyllis C ZeeCenter for Circadian and Sleep Medicine, Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Christopher P LandriganDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts.
Charles A CzeislerDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts.
Steven W LockleyDivision of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, Massachusetts.
ROSTERS STUDY GROUP
Brigham and Women's Hospital · USHarvard University · USBoston Children's Hospital · USCalifornia Pacific Medical Center · USCincinnati Children's Hospital Medical Center · USCircadian (United States) · USInstitute of Behavioral Sciences · JPPain and Rehabilitation Medicine · USSeattle Children's Hospital · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Colorado Boulder · USUniversity of Iowa Stead Family Children’s Hospital · USUniversity of Virginia Children's Hospital · USUniversity of Washington · US

Funding

TRANSPLANTATION ANALYSIS OF CIRCADIAN RHYTHMS AND AGINGP01AG009975 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI QUAN, STUART F. · 1991 to 2018
$23.1M
Multi-Center Trial of Limiting PGY2&3 Resident Work Hours on Patient Safety-CCCU01HL111478 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CZEISLER, CHARLES A, LANDRIGAN, CHRISTOPHER PAUL · 2012 to 2017
$8.4M
Influence of sleep regularity on circadian rhythms, learning, performance, and moodR01HL128538 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KLERMAN, ELIZABETH B. · 2016 to 2019
$3.6M
Sleep duration required to restore performance during chronic sleep restrictionR01HL114088 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KLERMAN, ELIZABETH B. · 2012 to 2015
$3.1M
Impact of Eliminating Extended Duration Work Shifts on Resident Health and SafetyR01OH010300 · OH · BRIGHAM AND WOMEN'S HOSPITAL · PI BARGER, LAURA K. · 2013 to 2016
$2.8M
Multi-scale modeling of sleep behaviors in social networksR01GM105018 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI CZEISLER, CHARLES A, KLERMAN, ELIZABETH B. · 2013 to 2017
$2.4M
MULTI-CENTER TRIAL OF LIMITING PGY2&3 RESIDENT WORK HOURS ON PATIENT SAFETY-DCCU01HL111691 · NHLBI · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI STONE, KATIE L · 2012 to 2016
$1.9M
Sleep Duration Required to Restore Performance during Chronic Sleep RestrictionK24HL105664 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI KLERMAN, ELIZABETH B. · 2010 to 2019
$1.8M
Effects of Light and Melatonin on Contractions in Pregnant WomenR21HD086392 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI KLERMAN, ELIZABETH B. · 2016 to 2017
$488k
NHLBI NIH HHS K24 HL105664NHLBI NIH HHS R01 HL114088NHLBI NIH HHS R01 HL128538NHLBI NIH HHS U01 HL111478NHLBI NIH HHS U01 HL111691NIA NIH HHS P01 AG009975NICHD NIH HHS R21 HD086392NIGMS NIH HHS R01 GM105018NIOSH CDC HHS R01 OH010300
6 · The paper itself

Abstract

objectivesExtended-duration work rosters (EDWRs) with shifts of 24+ hours impair performance compared with rapid cycling work rosters (RCWRs) that limit shifts to 16 hours in postgraduate year (PGY) 1 resident-physicians. We examined the impact of a RCWR on PGY 2 and PGY 3 resident-physicians.

methodsData from 294 resident-physicians were analyzed from a multicenter clinical trial of 6 US PICUs. Resident-physicians worked 4-week EDWRs with shifts of 24+ hours every third or fourth shift, or an RCWR in which most shifts were ≤16 consecutive hours. Participants completed a daily sleep and work log and the 10-minute Psychomotor Vigilance Task and Karolinska Sleepiness Scale 2 to 5 times per shift approximately once per week as operational demands allowed.

resultsOverall, the mean (± SE) number of attentional failures was significantly higher (

conclusionsPerformance impairment due to EDWR is improved by limiting shift duration. These data and their correlation with SME rates highlight the impairment of neurobehavioral performance due to extended-duration shifts and have important implications for patient safety.

Indexed as

Internship and ResidencyAdultAttentionFemaleHumansIntensive Care Units, PediatricMaleMedical ErrorsPsychomotor PerformanceShift Work ScheduleSleep DeprivationSleepinessTask Performance and AnalysisTime FactorsWakefulnessWorkload

Identifiers

PMID33619044
PMCPMC7919117
OpenAlexW3130103865

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.