Evidence map›Paper›PMID 33618966›Full record

ArticleClinical nutrition (Edinburgh, Scotland)2021

Omega-3 polyunsaturated fatty acids modify the inverse association between systemic inflammation and cardiovascular fitness.

Gabrielle Farley, Daniel W Riggs, Aruni Bhatnagar, Jason Hellmann

Open access · greenAbstract read
In one paragraph

Article in Clinical nutrition (Edinburgh, Scotland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. α-Linolenic Acid and Risk of Heart Failure: A Meta-Analysis.Frontiers in cardiovascular medicine · 2021
    Pooled it
  2. Review
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Gabrielle FarleyDiabetes and Obesity Center, Christina Lee Brown Envirome Institute, Division of Environmental Medicine, Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA; School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA.
Daniel W RiggsDiabetes and Obesity Center, Christina Lee Brown Envirome Institute, Division of Environmental Medicine, Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA; Department of Epidemiology and Population Health, University of Louisville, Louisville, KY, USA.
Aruni BhatnagarDiabetes and Obesity Center, Christina Lee Brown Envirome Institute, Division of Environmental Medicine, Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA.
Jason HellmannDiabetes and Obesity Center, Christina Lee Brown Envirome Institute, Division of Environmental Medicine, Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA. Electronic address: Jason.hellmann@louisville.edu.
University of Louisville · US

Funding

TBDP30GM127607 · NIGMS · UNIVERSITY OF LOUISVILLE · PI BHATNAGAR, ARUNI · 2018 to 2022
$6.3M
Exercise-enhanced resolution of inflammationR01GM127495 · NIGMS · UNIVERSITY OF LOUISVILLE · PI HELLMANN, JASON L · 2018 to 2022
$2.5M
NIGMS NIH HHS P30 GM127607NIGMS NIH HHS R01 GM127495
6 · The paper itself

Abstract

BACKGROUND AND

objectiveExercise increases quality of life and lowers all-cause mortality, likely by preventing cardiovascular disease. Although the beneficial effects of exercise are linked with reductions in chronic inflammation, individual responses vary and factors that contribute to the anti-inflammatory effects of cardiovascular fitness remain largely undefined. We sought to investigate the role of fatty acids in the inverse relationship between inflammation and cardiovascular fitness. APPROACH AND

resultsIn this cross-sectional study using data from 435 participants in NHANES and linear regression models with CRP as the outcome, we observed significant negative interactions between VO

conclusionsThis study suggests that omega-3 PUFAs are effect modifiers for VO

Indexed as

AdultAnti-Inflammatory AgentsCardiorespiratory FitnessCardiovascular SystemC-Reactive ProteinCross-Sectional StudiesExerciseFatty Acids, Omega-3Fatty Acids, Omega-6FemaleHumansInflammationLinear ModelsMaleNutrition SurveysOxygen ConsumptionAnti-Inflammatory AgentsC-Reactive ProteinFatty Acids, Omega-3Fatty Acids, Omega-6CardiovascularCRPExerciseInflammationOmega-3

Identifiers

PMID33618966
PMCPMC8243787
OpenAlexW3130669435

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.