Evidence map›Paper›PMID 33618751›Full record

ArticleMolecular brain2021

Region-specific distribution of Olig2-expressing astrocytes in adult mouse brain and spinal cord.

Hui Wang, Liang Xu, Chuying Lai, Kaiyu Hou, Junliang Chen, Yaowei Guo, Abhijeet Sambangi, Shreya Swaminathan, Chunming Xie, Zheng Wu and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecular brain, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 54 citations in OpenAlex.

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  12. Astrocyte regional specialization is shaped by postnatal development.bioRxiv : the preprint server for biology · 2025
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  14. Genes · 2025
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  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Hui WangDepartment of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.
Liang XuGHM Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China.
Chuying LaiGHM Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China.
Kaiyu HouGHM Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China.
Junliang ChenGHM Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China.
Yaowei GuoGHM Institute of CNS Regeneration, Jinan University, Guangzhou, 510632, China.
Abhijeet SambangiDepartment of Biology, Huck Institutes of Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA.
Shreya SwaminathanDepartment of Biology, Huck Institutes of Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA.
Chunming XieDepartment of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China. chmxie@163.com.ORCID 0000-0002-5978-9689
Zheng WuDepartment of Biology, Huck Institutes of Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA. zhengwu@jnu.edu.cn.
Gong ChenDepartment of Biology, Huck Institutes of Life Sciences, Pennsylvania State University, University Park, PA, 16802, USA. gongchen@jnu.edu.cn.
Jinan University · CNPennsylvania State University · USZhongda Hospital Southeast University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Olig2 is an important transcription factor essential for the specification and differentiation of oligodendrocytes as well as astrocytes and neurons during developmental stages. However, Olig2 distribution pattern and its relationship among different types of glial cells in the adult central nervous system (CNS) are not well characterized. Here, we systematically examined Olig2 expression pattern in combination with major markers of neurons and glial cells throughout the brain and spinal cord in the adult mice. As expected, Olig2 is universally expressed in oligodendrocytes and oligodendrocyte precursor cells (OPCs), but not in neurons or microglia. Interestingly, we discover a subpopulation of Olig2

Indexed as

2',3'-Cyclic-Nucleotide PhosphodiesterasesAgingAnimalsAntigensAstrocytesBrainChondroitin Sulfate Proteoglycan 4DNA-Binding ProteinsMiceMice, Inbred C57BLNerve Tissue ProteinsNeural Stem CellsNeurogliaNeuronsOligodendrocyte Transcription Factor 2Oligodendroglia2',3'-Cyclic-Nucleotide PhosphodiesterasesAntigensChondroitin Sulfate Proteoglycan 4DNA-Binding ProteinsNerve Tissue ProteinsNeuN protein, mouseOlig2 protein, mouseOligodendrocyte Transcription Factor 2ProteoglycansAstrocyteBrainCentral nervous systemMicrogliaNeuronOlig2OligodendrocyteSpinal cord

Identifiers

PMID33618751
PMCPMC7901088
OpenAlexW3128662823

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.