Evidence map›Paper›PMID 33618602›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2021

Challenging inflammatory process at molecular, cellular and in vivo levels via some new pyrazolyl thiazolones.

Perihan A Elzahhar, Rana A Alaaeddine, Rasha Nassra, Azza Ismail, Hala F Labib, Mohamed G Temraz, Ahmed S F Belal, Ahmed F El-Yazbi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 13 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Perihan A ElzahharDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Rana A AlaaeddineDepartment of Pharmacology and Toxicology, Faculty of Medicine and Medical Centre, American University of Beirut, Beirut, Lebanon.
Rasha NassraDepartment of Medical Biochemistry, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Azza IsmailDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Hala F LabibDepartment of Pharmaceutical Chemistry, College of Pharmacy, Arab Academy of Science Technology and Maritime Transport, Alexandria, Egypt.
Mohamed G TemrazFaculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Ahmed S F BelalDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Ahmed F El-YazbiDepartment of Pharmacology and Toxicology, Faculty of Medicine and Medical Centre, American University of Beirut, Beirut, Lebanon.
Alexandria University · EGAmerican University of Beirut · LBArab Academy for Science, Technology, and Maritime Transport · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The work reported herein describes the synthesis of a new series of anti-inflammatory pyrazolyl thiazolones. In addition to COX-2/15-LOX inhibition, these hybrids exerted their anti-inflammatory actions through novel mechanisms. The most active compounds possessed COX-2 inhibitory activities comparable to celecoxib (IC

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalAnti-Ulcer AgentsApoptosisCell DifferentiationCell SurvivalCytokinesDisease Models, AnimalEdemaFemaleFormaldehydeHumansInflammationMacrophagesModels, MolecularPyrazolesAnti-Inflammatory Agents, Non-SteroidalAnti-Ulcer AgentsCytokinesFormaldehydePyrazolesThiazoles15-lipoxygenaseanti-inflammatorycyclooxygenase-1/cyclooxygenase-2macrophage apoptosisPyrazolyl thiazolones

Identifiers

PMID33618602
PMCPMC7901699
OpenAlexW3132586289

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.