Evidence map›Paper›PMID 33618570›Full record

ArticleOtolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery2021

Microscopic Extranodal Extension in HPV-Negative Head and Neck Cancer and the Role of Adjuvant Chemoradiation.

Flora Yan, Hong Li, John R de Almeida, John M Kaczmar, Patrik Pipkorn, Joseph Zenga, Mary S Richardson, David M Neskey, Anand K Sharma, Terry A Day and 1 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. [Advances in the diagnosis and prognosis of extranodal extension in head and neck squamous cell carcinoma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Flora YanDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Hong LiDepartment of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
John R de AlmeidaDepartment of Otolaryngology-Head and Neck Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada.
John M KaczmarDivision of Medical Oncology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
Patrik PipkornDepartment of Otolaryngology-Head and Neck Surgery, Washington University, St Louis, Missouri, USA.
Joseph ZengaDepartment of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Mary S RichardsonDepartment of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
David M NeskeyDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Anand K SharmaDepartment of Radiation Oncology, Medical University of South Carolina, Charleston, South Carolina, USA.
Terry A DayDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Evan M GraboyesDepartment of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.
Medical University of South Carolina · USMedical College of Wisconsin · USUniversity Health Network · CAWashington University in St. Louis · US

Funding

Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND N. DUBOIS · 2009 to 2026
$42.7M
NCI NIH HHS P30 CA138313
6 · The paper itself

Abstract

objectivePathologic extranodal extension (ENE) is an important adverse feature for human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC), but the prognostic significance of microscopic ENE (ENE STUDY

designRetrospective cohort study.

settingCommission on Cancer (CoC)-accredited facilities.

methodsThis retrospective cohort study included patients in the National Cancer Database from 2009 to 2015 with pathologic node-positive (pN+) HPV-negative HNSCC with either pathologic ENE

resultsWe included 5483 patients with pN+ HPV-negative HNSCC, of whom 24% had ENE

conclusionFor patients with HPV-negative HNSCC, pN+ with ENE

Indexed as

Extranodal ExtensionAgedCarcinoma, Squamous CellChemoradiotherapy, AdjuvantHead and Neck NeoplasmsHumansMaleMargins of ExcisionMiddle AgedNeck DissectionPrognosisRetrospective StudiesSurvival RateUnited Statesadjuvant therapyextranodal extensionhead and neck squamous cell carcinoma

Identifiers

PMID33618570
PMCPMC8380754
OpenAlexW3131482466

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.