SynthesisCartilage2021
Evidence-based Treatment of Failed Primary Osteochondral Lesions of the Talus: A Systematic Review on Clinical Outcomes of Bone Marrow Stimulation.
Synthesis in Cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Risk factors and clinical significance of functional outcomes after microfracture-based surgical treatment of osteochondral lesion of the talus.Journal of orthopaedic surgery and research · 2026Article
- Arthroscopic Bone Marrow Stimulation for Non-primary Osteochondral Lesions of the Talus Yields Limited Improvements in Patient-Reported Outcomes Compared to Primary Lesions: A Prospective 2-Year Follow-up Study.Foot & ankle international · 2026Article
- Lower limb malalignment on whole-leg radiography predicts medial or lateral talar osteochondral lesion location: Implications for osteoarthritis assessment.Osteoarthritis and cartilage open · 2026Article
- In silico assessment of talus osteochondral lesion size and location on biomechanical load distribution using tilted talar dome planes.Acta orthopaedica et traumatologica turcica · 2025Article
- Operative Treatment of Nonprimary Osteochondral Lesions of the Talus: A Systematic Review.Orthopaedic journal of sports medicine · 2024Review
- [Progress in surgical treatment of osteochondral lesion of talus].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024Review
- The Biomechanical Influence of Defected Cartilage on the Progression of Osteochondral Lesions of the Talus: A Three-dimensional Finite Element Analysis.Orthopaedic surgery · 2023Article
- Radiographic and Clinical Outcomes After Arthroscopic Microfracture for Osteochondral Lesions of the Talus: 5-Year Results in 355 Consecutive Ankles.Orthopaedic journal of sports medicine · 2022Article
- Autologous matrix induced chondrogenesis (AMIC) as revision procedure for failed AMIC in recurrent symptomatic osteochondral defects of the talus.Scientific reports · 2022Article
- The effect of talus osteochondral defects of different area size on ankle joint stability: a finite element analysis.BMC musculoskeletal disorders · 2022Article
- The management of talar osteochondral lesions - Current concepts.Journal of arthroscopy and joint surgeryReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe purpose of this study is to systematically review the literature and to evaluate the outcomes following bone marrow stimulation (BMS) for nonprimary osteochondral lesions of the talus (OLT).
designA literature search was performed to identify studies published using PubMed (MEDLINE), EMBASE, CDSR, DARE, and CENTRAL. The review was performed according to the PRISMA guidelines. Two authors separately and independently screened the search results and conducted the quality assessment using the Methodological Index for Non-Randomized Studies (MINORS). Studies were pooled on clinical, sports, work, and imaging outcomes, as well as revision rates and complications. The primary outcome was clinical success rate.
resultsFive studies with 70 patients were included in whom nonprimary OLTs were treated with secondary BMS. The pooled clinical success rate was 61% (95% confidence interval [CI], 50-72). The rate of return to any level of sport was 83% (95% CI, 70-91), while the return to pre-injury level of sport was 55% (95% CI, 34-74). The rate of return to work was 92% (95% CI, 78-97), and the complication rate was assessed to be 10% (95% CI, 4-22). Imaging outcomes were heterogeneous in outcome assessment, though a depressed subchondral bone plate was observed in 91% of the patients. The revision rate was 27% (95% CI, 18-40).
conclusionsThe overall success rate of arthroscopic BMS for nonprimary osteochondral lesions of the talus was 61%, including a revision rate of 27%. Return to sports, work, and complication outcomes yielded fair to good results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.