ArticleJournal of preventive medicine and public health = Yebang Uihakhoe chi2021
Associations Between Thyroid Hormone Levels and Urinary Concentrations of Bisphenol A, F, and S in 6-Year-old Children in Korea.
Article in Journal of preventive medicine and public health = Yebang Uihakhoe chi, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Temporal and geographic variability of bisphenol levels in humans: A systematic review and meta-analysis of international biomonitoring data.Environmental research · 2025Pooled it
- Maternal bisphenols exposure and thyroid function in children: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- The Impact of Bisphenol A on Thyroid Function in Neonates and Children: A Systematic Review of the Literature.Nutrients · 2021Pooled it
- Bisphenol A and its analogues in thyroid diseases: Evidence from dysfunction, autoimmunity, and cancer.iScience · 2026Review
- Integrated transcriptome analysis of rats exposed to bisphenol mixtures from the fetal to developmental stage.Toxicology research · 2025Article
- Evaluation of the Relationship Between Thyroid Hormone Levels and Bisphenol A in Children Aged 6-14 Years.Clinical endocrinology · 2025Article
- Relationship of urinary bisphenol A in childhood on thyroid hormone function in adolescents: a cohort study.PloS one · 2025Article
- Exposure of elementary school-aged Brazilian children to bisphenol A: association with demographic, social, and behavioral factors, and a worldwide comparison.Scientific reports · 2024Article
- Relationship between bisphenol A and autoimmune thyroid disease in women of childbearing age.Frontiers in endocrinology · 2024Article
- Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesBisphenol A (BPA) is used in the electrical, mechanical, medical, and food industries. Previous studies have suggested that BPA is an endocrine disruptor. Regulation of BPA has led to increased use of bisphenol F (BPF) and bisphenol S (BPS). However, few studies have investigated the associations of BPF and BPS with thyroid dysfunction in children. Our study investigated the associations of prenatal BPA and early childhood BPA, BPF, and BPS exposure with thyroid function in 6-year-old children.
methodsPrenatal BPA concentrations were measured during the second trimester of pregnancy in an established prospective birth cohort. We measured urinary BPA, BPF, and BPS concentrations and thyroid hormone levels (thyroid-stimulating hormone, total T3, and free T4) in 6-year-old children (n=574). We examined the associations between urinary bisphenol concentrations and percentage change of thyroid hormone concentrations using multivariate linear regression. We also compared thyroid hormone levels by dividing the cohort according to BPA, BPF, and BPS concentrations.
resultsThe associations between prenatal BPA and total T3 levels were statistically significant in all models, except for girls when using a crude model. The associations between urinary BPA and BPS concentrations and levels of all thyroid hormones were not statistically significant. However, we observed that lower free T4 levels (-1.94%; 95% confidence interval, -3.82 to -0.03) were associated with higher urinary BPF concentrations in girls only.
conclusionsOur findings identified significant associations between prenatal BPA exposure and total T3 levels in all children and between BPF exposure and free T4 levels in girls only.
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Registered trials
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