Evidence map›Paper›PMID 33618432›Full record

Trial reportBritish journal of haematology2021

Flow cytometric immunophenotypic alterations of persistent clonal haematopoiesis in remission bone marrows of patients with NPM1-mutated acute myeloid leukaemia.

Sanam Loghavi, Courtney D DiNardo, Ken Furudate, Koichi Takahashi, Tomoyuki Tanaka, Nicholas J Short, Tapan Kadia, Marina Konopleva, Rashmi Kanagal-Shamanna, Noushin R Farnoud and 10 more

Open access · bronzeAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in British journal of haematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 46 citations in OpenAlex.

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  12. Acute Myeloid Leukemia-Use of Measurable Residual Disease to Improve Outcomes.Advances in experimental medicine and biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 2 institutions in 2 countries.

Sanam LoghaviThe Department of Hematopathology, MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-8980-3202
Courtney D DiNardoThe Department of Leukemia, MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-9003-0390
Ken FurudateThe Department of Leukemia, MD Anderson Cancer Center, Houston, TX, USA.
Koichi TakahashiThe Department of Leukemia, MD Anderson Cancer Center, Houston, TX, USA.
Tomoyuki TanakaThe Department of Leukemia, MD Anderson Cancer Center, Houston, TX, USA.
Nicholas J ShortThe Department of Leukemia, MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-2983-2738
Tapan KadiaThe Department of Leukemia, MD Anderson Cancer Center, Houston, TX, USA.
Marina KonoplevaThe Department of Leukemia, MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-9347-2212
Rashmi Kanagal-ShamannaThe Department of Hematopathology, MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-7829-5249
Noushin R FarnoudCenter for Hematologic Malignancies, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sherry PierceThe Department of Leukemia, MD Anderson Cancer Center, Houston, TX, USA.
Joseph D KhouryThe Department of Hematopathology, MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-2621-3584
Jeffrey L JorgensenThe Department of Hematopathology, MD Anderson Cancer Center, Houston, TX, USA.
Keyur P PatelThe Department of Hematopathology, MD Anderson Cancer Center, Houston, TX, USA.
Naval DaverThe Department of Leukemia, MD Anderson Cancer Center, Houston, TX, USA.
Musa YilmazThe Department of Leukemia, MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-4498-4895
L Jeffrey MedeirosThe Department of Hematopathology, MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-6577-8006
Hagop KantarjianThe Department of Leukemia, MD Anderson Cancer Center, Houston, TX, USA.
Farhad RavandiThe Department of Leukemia, MD Anderson Cancer Center, Houston, TX, USA.
Sa A WangThe Department of Hematopathology, MD Anderson Cancer Center, Houston, TX, USA.
The University of Texas MD Anderson Cancer Center · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Clonal haematopoiesis (CH) in patients with acute myeloid leukaemia (AML) may persist beyond attaining complete remission. From a consecutive cohort of 67 patients with nucleophosmin 1-mutated (NPM1

Indexed as

Bone MarrowClonal HematopoiesisLeukemia, Myeloid, AcuteMutationMyeloid Progenitor CellsNeoplasm ProteinsNuclear ProteinsAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedNucleophosminRemission InductionNeoplasm ProteinsNPM1 protein, humanNuclear ProteinsNucleophosminAMLClonal hematopoiesisMRDNPM1

Identifiers

PMID33618432
PMCPMC8944196
OpenAlexW3131323362

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.