Evidence map›Paper›PMID 33618329›Full record

ArticleJournal of biomechanics2021

Natural oscillatory modes of 3D deformation of the human brain in vivo.

J D Escarcega, A K Knutsen, R J Okamoto, D L Pham, P V Bayly

Abstract read
In one paragraph

Article in Journal of biomechanics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

J D EscarcegaMechanical Engineering and Materials Science, Washington University in St. Louis, MO, United States. Electronic address: jescarcega@wustl.edu.
A K KnutsenCenter for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States.
R J OkamotoMechanical Engineering and Materials Science, Washington University in St. Louis, MO, United States.
D L PhamCenter for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States.
P V BaylyMechanical Engineering and Materials Science, Washington University in St. Louis, MO, United States.

Funding

IN VIVO MEASUREMENT OF BRAIN BIOMECHANICSR01NS055951 · NINDS · WASHINGTON UNIVERSITY · PI BAYLY, PHILIP V · 2007 to 2017
$3.9M
MRI Measurement of the Mechanical Vulnerability of the BrainU01NS112120 · NINDS · WASHINGTON UNIVERSITY · PI BAYLY, PHILIP V · 2019 to 2023
$3.7M
In Vivo Measurement of Brain BiomechanicsR56NS055951 · NINDS · WASHINGTON UNIVERSITY · PI BAYLY, PHILIP V · 2018 to 2018
$563k
NINDS NIH HHS R01 NS055951NINDS NIH HHS R56 NS055951NINDS NIH HHS U01 NS112120
6 · The paper itself

Abstract

Natural modes and frequencies of three-dimensional (3D) deformation of the human brain were identified from in vivo tagged magnetic resonance images (MRI) acquired dynamically during transient mild acceleration of the head. Twenty 3D strain fields, estimated from tagged MRI image volumes in 19 adult subjects, were analyzed using dynamic mode decomposition (DMD). These strain fields represented dynamic, 3D brain deformations during constrained head accelerations, either involving rotation about the vertical axis of the neck or neck extension. DMD results reveal fundamental oscillatory modes of deformation at damped frequencies near 7 Hz (in neck rotation) and 11 Hz (in neck extension). Modes at these frequencies were found consistently among all subjects. These characteristic features of 3D human brain deformation are important for understanding the response of the brain in head impacts and provide valuable quantitative criteria for the evaluation and use of computer models of brain mechanics.

Indexed as

BrainMagnetic Resonance ImagingAccelerationAdultHeadHumansRotationBrain mechanicsDynamic mode decompositionNatural frequencyOscillationsTagged MRITraumatic brain injury

Identifiers

PMID33618329
PMCPMC8055167

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.