ArticleDrug and alcohol dependence2021
Evaluation of the Addictions Neuroclinical Assessment (ANA) framework through deep phenotyping of problem drinkers.
Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Review
- Diagnostic validity of Addictions Neuroclinical Assessment indices for alcohol use disorder: Findings from an observational case-control study.Addiction (Abingdon, England) · 2026Observational
- Behavioral phenotypes associated with cannabis and alcohol substitution.Harm reduction journal · 2026Observational
- G9a inhibition reduces stress-potentiated alcohol drinking in both male and female mice: Implications for safe and effective pharmacological therapeutics for alcohol use disorder.Alcohol, clinical & experimental research · 2026Article
- Machine learning-based computational validation of the Addictions Neuroclinical Assessment framework in relation to hazardous drinking.Journal of psychiatry & neuroscience : JPN · 2026Article
- Increased alcohol-biased choice behavior in mouse models of high alcohol drinking.Alcohol, clinical & experimental research · 2025Article
- Early life stress is associated with greater negative emotionality and peripheral inflammation in alcohol use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Mapping Dialectical Behavior Therapy Skills to Clinical Domains Implicated in Contemporary Addiction Research: A Conceptual Synthesis and Promise for Precision Medicine.Cognitive and behavioral practice · 2024Article
- Longitudinal measurement invariance of constructs derived from the addiction cycle.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2024Article
- Factors underlying the neurofunctional domains of the Addictions Neuroclinical Assessment assessed by a standardized neurocognitive battery.Translational psychiatry · 2024Observational
- Neural correlates of the addictions neuroclinical assessment (ANA) incentive salience factor among individuals with alcohol use disorder.Behavioural brain research · 2024Article
- Examining the validity of the addictions neuroclinical assessment domains in a crowdsourced sample of adults with current alcohol use.Experimental and clinical psychopharmacology · 2024Article
- Development and clinical feasibility study of a brief version of an addiction-focused phenotyping battery in females receiving buprenorphine for opioid use disorder.Brain and behavior · 2023Article
- New approaches to deep phenotyping in addictions.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023Review
- Constructs derived from the addiction cycle predict alcohol use disorder treatment outcomes and recovery 3 years following treatment.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023Article
- Neurobiology and the Treatment of Alcohol Use Disorder: A Review of the Evidence Base.Substance abuse and rehabilitation · 2023Review
- Translational models of addiction phenotypes to advance addiction pharmacotherapy.Annals of the New York Academy of Sciences · 2023Review
- Applying the Addictions Neuroclinical Assessment to derive neurofunctional domains in individuals who use methamphetamine.Behavioural brain research · 2022Article
- Targeting Unmet Clinical Needs in the Treatment of Alcohol Use Disorder.Frontiers in psychiatry · 2022Review
- A scoping review of electroencephalographic (EEG) markers for tracking neurophysiological changes and predicting outcomes in substance use disorder treatment.Frontiers in human neuroscience · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundTo advance the development of a neuroscience-informed understanding of alcohol use disorder (AUD) through the Addictions Neuroclinical Assessment (ANA) framework, the present study reports on deep phenotyping of a large sample of problem drinkers.
methodsParticipants (n = 1679) were primarily heavy drinkers with and without AUD, who completed a phenotypic battery of well-validated scales and behavioral measures of alcohol use and problems, mood, attention, and impulsivity. These scales were subjected to sequential factor analytic work in order to derive a factor solution that explains biobehavioral variation in the sample. To assess the construct validity of the resulting factor solution, scores on each factor were associated with demographic and clinical indicators.
resultsFactor analysis techniques using indicators of alcohol use and problems, mood, attention, and impulsivity implicated four functional domains that compliment and extend the proposed ANA domains: negative alcohol-related consequences, incentive salience, negative emotionality, and executive function. Demographic and clinical variables significantly predicted scores on all ANA domains.
conclusionsThis study provides an independent test of the recently proposed neuroscience-based ANA framework. Results largely support the novel approach in identifying four core constructs in problem drinkers. Future studies can deepen our understanding of how these domains are relevant to AUD by incorporating biomarkers.
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