ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021
Characterizing SARS-CoV-2 genome diversity circulating in South American countries: Signatures of potentially emergent lineages?
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Natural SARS-CoV- 2 infection in domestic cats and dogs of humans diagnosed with COVID-19 in Valle de Aburrá, AntioquiaBiomedica : revista del Instituto Nacional de Salud · 2022Article
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- Insights into the mutation T1117I in the spike and the lineage B.1.1.389 of SARS-CoV-2 circulating in Costa Rica.Gene reports · 2022Article
- Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant.BMC medicine · 2022Article
- Clinical Comparative Evaluation of the LabTurboInfection and drug resistance · 2022Article
- Genetic diversity of SARS-CoV-2 in South America: demographic history and structuration signals.Archives of virology · 2021Article
- Pseudoephedrine and its derivatives antagonize wild and mutated severe acute respiratory syndrome-CoV-2 viruses through blocking virus invasion and antiinflammatory effect.Phytotherapy research : PTR · 2021Article
- SARS-CoV-2 in Transit: Characterization of SARS-CoV-2 Genomes From Venezuelan Migrants in Colombia.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Article
- An Overview of Vaccines against SARS-CoV-2 in the COVID-19 Pandemic Era.Pathogens (Basel, Switzerland) · 2021Review
- Article
- Phylogenomic Evidence of Reinfection and Persistence of SARS-CoV-2: First Report from Colombia.Vaccines · 2021Article
- Lock or Down: Effectiveness of Isolation Measures Against COVID-19.Clinics (Sao Paulo, Brazil) · 2021Article
- New Brazilian variant of the SARS-CoV-2 (P1/Gamma) of COVID-19 in Alagoas state.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
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5 authors.
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Abstract
objectivesTo evaluate the genomic diversity and geographic distribution of SARS-CoV-2 lineages in South America.
methodsSARS-CoV-2 lineages from a public dataset of 5583 South American genome assemblies were analyzed. Polymorphisms in the main open reading frames were identified and compared to those in the main lineages of epidemiological concern: B.1.1.7 (UK) and B.1.351 (South Africa).
resultsAcross 16 South American countries, 169 lineages were identified; major lineage B had the greatest diversity and broadest geographic distribution. Seventeen predominant lineages were analyzed revealing 2 dominant lineages of concern: P.1 (Brazilian variant) and B.1.1.7 with 94 and 28 genomes, respectively, both with 33 polymorphisms (other lineages displayed ≤24 polymorphisms). A high number of polymorphisms were detected with a limited number of common variable positions, in common with the profile of the main lineages of epidemiological concern.
conclusionsThe ever-increasing genetic diversity of SARS-CoV-2 continues to lead to novel lineage emergence. Various variants and lineages are now present across South America, dominated by major lineage B. The circulation of P.1 and B.1.1.7 and the high number of polymorphisms highlight the importance of genomic surveillance to determine introduction events, identify transmission chains, trace emergence, and implement prevention, vaccination and control strategies.
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