Evidence map›Paper›PMID 33617898›Full record

ArticleJournal of molecular biology2021

Altering CLC stoichiometry by reducing non-polar side-chains at the dimerization interface.

Kacey Mersch, Tugba N Ozturk, Kunwoong Park, Hyun-Ho Lim, Janice L Robertson

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. A thermodynamic analysis of CLC transporter dimerization in lipid bilayers.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Kacey MerschDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Department of Molecular Physiology and Biophysics, The University of Iowa, Iowa City, IA, USA.
Tugba N OzturkDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Kunwoong ParkDepartment of Structure and Function of Neural Network, Korea Brain Research Institute, 41068 Daegu, Republic of Korea.
Hyun-Ho LimDepartment of Structure and Function of Neural Network, Korea Brain Research Institute, 41068 Daegu, Republic of Korea; Department of Brain & Cognitive Sciences, Daegu Gyeongbuk Institute of Science & Technology, 42988 Daegu, Republic of Korea.
Janice L RobertsonDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA. Electronic address: janice.robertson@wustl.edu.
Washington University in St. Louis · USDaegu Gyeongbuk Institute of Science and Technology · KRKorea Brain Research Institute · KRUniversity of Iowa · US

Funding

Driving forces of membrane protein assembly in membranesR01GM120260 · NIGMS · WASHINGTON UNIVERSITY · PI ROBERTSON, JANICE L · 2016 to 2024
$3.4M
Debugging eukaryotic membrane protein expression in E. coli using single-molecule fluorescence microscopyR21GM126476 · NIGMS · WASHINGTON UNIVERSITY · PI ROBERTSON, JANICE L · 2018 to 2019
$427k
NIGMS NIH HHS R01 GM120260NIGMS NIH HHS R21 GM126476
6 · The paper itself

Abstract

CLC-ec1 is a Cl

Indexed as

DimerizationAntiportersEscherichia coliEscherichia coli ProteinsLipid BilayersMicellesMutationSingle Molecule ImagingAntiportersCLC-ec1 protein, E coliEscherichia coli ProteinsLipid BilayersMicellesCLC-ec1lipid bilayermembrane proteinoligomerizationvan der Waals

Identifiers

PMID33617898
PMCPMC8734038
OpenAlexW3131658164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.