Evidence map›Paper›PMID 33617672›Full record

ArticleAmerican journal of hematology2021

A Phase I dose-escalation study of DCLL9718S, an antibody-drug conjugate targeting C-type lectin-like molecule-1 (CLL-1) in patients with acute myeloid leukemia.

Naval Daver, Amandeep Salhotra, Joseph M Brandwein, Nikolai A Podoltsev, Daniel A Pollyea, Joseph G Jurcic, Sarit Assouline, Karen Yee, Mengsong Li, Tony Pourmohamad and 6 more

Open access · hybridAbstract readClinical Trial, Phase ILetter
In one paragraph

Article in American journal of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Phase 1 Study of KITE-222, an Autologous CLL-1-Directed CAR T-cell Therapy in Patients with Relapsed/Refractory Acute Myeloid Leukemia.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 3 countries.

Naval DaverDepartment of Leukemia, MD Anderson Cancer Center, Houston, Texas.ORCID 0000-0001-7103-373X
Amandeep SalhotraCity of Hope Comprehensive Cancer Center, Duarte, California.ORCID 0000-0002-9302-5041
Joseph M BrandweinUniversity of Alberta Hospital, Edmonton, Alberta, Canada.ORCID 0000-0001-9095-8789
Nikolai A PodoltsevYale University School of Medicine, New Haven, Connecticut.
Daniel A PollyeaDivision of Hematology, Department of Medicine, University of Colorado, Aurora, Colorado.
Joseph G JurcicColumbia University Irving Medical Center, New York Presbyterian Hospital, and Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York.
Sarit AssoulineJewish General Hospital, McGill University, Montreal, Quebec, Canada.
Karen YeeDepartment of Medical Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada.
Mengsong LiGenentech, Inc., South San Francisco, California.
Tony PourmohamadGenentech, Inc., South San Francisco, California.
Divya SamineniGenentech, Inc., South San Francisco, California.
Teiko SumiyoshiGenentech, Inc., South San Francisco, California.
Anjali VazeGenentech, Inc., South San Francisco, California.
Randall C DereGenentech, Inc., South San Francisco, California.
Connie MaGenentech, Inc., South San Francisco, California.
James CooperGenentech, Inc., South San Francisco, California.
Kaiser Permanente South San Francisco Medical Center · USAlberta Hospital Edmonton · CACity of Hope · USJewish General Hospital · CANewYork–Presbyterian Hospital · USPrincess Margaret Cancer Centre · CAThe University of Texas MD Anderson Cancer Center · USUniversity of Colorado Anschutz Medical Campus · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedAged, 80 and overAntibodiesAntineoplastic AgentsChemical and Drug Induced Liver InjuryDose-Response Relationship, DrugEarly Termination of Clinical TrialsFemaleHumansImmunoconjugatesLectins, C-TypeLeukemia, Myeloid, AcuteMaleMiddle AgedMutationAntibodiesAntineoplastic AgentsCLEC12A protein, humanDCLL9718SImmunoconjugatesLectins, C-TypeNeoplasm ProteinsReceptors, Mitogen

Identifiers

PMID33617672
PMCPMC8252033
OpenAlexW3131061582

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.