Evidence map›Paper›PMID 33617476›Full record

ArticleThe American journal of tropical medicine and hygiene2021

No Evidence of O'nyong-nyong Viremia among Children with Febrile Illness in Kenya (2015-2018).

Melisa M Shah, Bryson A Ndenga, Francis M Mutuku, Victoria Okuta, Charles O Ronga, Philip K Chebii, Priscilla Maina, Zainab Jembe, Malaya K Sahoo, ChunHong Huang and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Chikungunya virus antepartum transmission and abnormal infant outcomes in a cohort of pregnant women in Nigeria.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2024
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Melisa M Shah1Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.
Bryson A Ndenga2Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Francis M Mutuku3Department of Environment and Health Sciences, Technical University of Mombasa, Mombasa, Kenya.
Victoria Okuta2Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Charles O Ronga2Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Philip K Chebii4Msambweni County Referral Hospital, Msambweni, Kenya.
Priscilla Maina4Msambweni County Referral Hospital, Msambweni, Kenya.
Zainab Jembe5Diani Health Center, Ukunda, Kenya.
Malaya K Sahoo6Department of Pathology, Stanford University School of Medicine, Stanford, California.
ChunHong Huang6Department of Pathology, Stanford University School of Medicine, Stanford, California.
Jenna Weber6Department of Pathology, Stanford University School of Medicine, Stanford, California.
Benjamin A Pinsky1Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California.
Angelle Desiree LaBeaud7Division of Infectious Disease, Department of Pediatrics, Stanford University School of Medicine, Stanford, California.
Stanford University · USKenya Medical Research Institute · KETechnical University of Mombasa · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

O'nyong-nyong virus (ONNV) is a little-known arbovirus causing intermittent, yet explosive, outbreaks in Africa. It is closely related to chikungunya virus, an emerging infectious disease. O'nyong-nyong virus causes a self-limited illness characterized by bilateral polyarthritis, rash, low-grade fever, and lymphadenopathy. In 1959, an extensive outbreak of ONNV occurred in East Africa, and decades later, another large outbreak was documented in Uganda in 1996. Limited evidence for interepidemic transmission is available, although serologic studies indicate a high prevalence of exposure. 1,045 febrile child participants in western and coastal Kenya were tested for the presence of ONNV using a multiplexed real-time reverse transcriptase-PCR assay. More than half of the participants had malaria parasitemia, and there was no evidence of active ONNV viremia in these participants. Further work is required to better understand the interepidemic circulation of ONNV and to reconcile evidence of high serologic exposure to ONNV among individuals in East Africa.

Indexed as

AdolescentAlphavirus InfectionsChildChild, PreschoolCommunicable Diseases, EmergingDisease OutbreaksFeverHumansInfantKenyaO'nyong-nyong VirusSeroepidemiologic StudiesViremia

Identifiers

PMID33617476
PMCPMC8045621
OpenAlexW3130109064

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.