Evidence map›Paper›PMID 33617318›Full record

ArticleEnvironmental health perspectives2021

Environmental Spread of Extended Spectrum Beta-Lactamase (ESBL) Producing

Liseth Salinas, Fernanda Loayza, Paúl Cárdenas, Carlos Saraiva, Timothy J Johnson, Heather Amato, Jay P Graham, Gabriel Trueba

Abstract read
In one paragraph

Article in Environmental health perspectives, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Risk factors for antimicrobial-resistantFrontiers in veterinary science · 2024
    Pooled it
  2. Article
  3. Article
  4. Extended-Spectrum β-Lactamase-ProducingAnimals : an open access journal from MDPI · 2026
    Article
  5. Antimicrobial-resistantmedRxiv : the preprint server for health sciences · 2026
    Article
  6. Antimicrobial resistantOne health (Amsterdam, Netherlands) · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Genomic Diversity and Extended-SpectrumInternational journal of microbiology · 2026
    Article
  14. Article
  15. Antimicrobial Resistance Phenotypes and Genotypes ofAntibiotics (Basel, Switzerland) · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Environmental Exposures and the Human Gut Resistome in Northwest Ecuador.medRxiv : the preprint server for health sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liseth SalinasInstituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, Pichincha, Ecuador.
Fernanda LoayzaInstituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, Pichincha, Ecuador.
Paúl CárdenasInstituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, Pichincha, Ecuador.
Carlos SaraivaInstituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, Pichincha, Ecuador.
Timothy J JohnsonDepartment of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, Minnesota, USA.
Heather AmatoEnvironmental Health Sciences Division, University of California, Berkeley, California, USA.
Jay P GrahamEnvironmental Health Sciences Division, University of California, Berkeley, California, USA.
Gabriel TruebaInstituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito, Quito, Pichincha, Ecuador.

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
Antimicrobial Resistance Transmission Associated with Small-Scale Food-Animal Production in Peri-Urban Communities of Quito, EcuadorR01AI135118 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI GRAHAM, JAY PAUL · 2018 to 2021
$2.0M
FIC NIH HHS D43 TW010540NIAID NIH HHS R01 AI135118
6 · The paper itself

Abstract

backgroundThere is a significant gap in our understanding of the sources of multidrug-resistant bacteria and resistance genes in community settings where human-animal interfaces exist.

objectivesThis study characterized the relationship of third-generation cephalosporin-resistant

methodsWe examined 3GCR-EC isolated from environmental fecal samples of domestic animals and child fecal samples in Ecuador. We analyzed phenotypic and genotypic AMR, as well as clonal relationships (CRs) based on pairwise single-nucleotide polymorphisms (SNPs) analysis of 3GCR-EC core genomes. CRs were defined as isolates with fewer than 100 different SNPs.

resultsA total of 264 3GCR-EC isolates from children ( DISCUSSION: This study provides evidence of highly dynamic horizontal transfer of AMR genes and mobile genetic elements (MGEs) in the

Indexed as

Escherichia coliEscherichia coli InfectionsAnimalsAnimals, DomesticAnti-Bacterial Agentsbeta-LactamasesChickensDogsEcuadorAnti-Bacterial Agentsbeta-Lactamases

Identifiers

PMID33617318
PMCPMC7899495

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.