Evidence map›Paper›PMID 33617235›Full record

ArticleACS infectious diseases2021

A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in

Asma Farjallah, Laurent R Chiarelli, Martin Forbak, Giulia Degiacomi, Mathieu Danel, Fernanda Goncalves, Chantal Carayon, Cendrine Seguin, Marco Fumagalli, Monika Záhorszká and 9 more

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Anti-tuberculosis drug developmentFrontiers in microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 6 countries.

Asma FarjallahITAV, Université de Toulouse, CNRS USR3505, UPS, 1 place Pierre Potier, 31106 Toulouse Cedex 1, France.
Laurent R ChiarelliDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, via Ferrata 9, 27100 Pavia, Italy.ORCID 0000-0003-0348-9764
Martin ForbakDepartment of Biochemistry, Comenius University in Bratislava, Faculty of Natural Sciences, Mlynská Dolina, Ilkovičova 6, 842 15 Bratislava, Slovakia.
Giulia DegiacomiDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, via Ferrata 9, 27100 Pavia, Italy.
Mathieu DanelITAV, Université de Toulouse, CNRS USR3505, UPS, 1 place Pierre Potier, 31106 Toulouse Cedex 1, France.
Fernanda GoncalvesITAV, Université de Toulouse, CNRS USR3505, UPS, 1 place Pierre Potier, 31106 Toulouse Cedex 1, France.
Chantal CarayonLaboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique (SPCMIB), Université Paul Sabatier-Toulouse III/CNRS (UMR5068), 118 route de Narbonne, F-31062 Toulouse, France.
Cendrine SeguinLaboratoire de Conception et Application de Molécules Bioactives (LCAMB), CNRS-UMR7199, Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, 67401 Illkirch, France.
Marco FumagalliDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, via Ferrata 9, 27100 Pavia, Italy.
Monika ZáhorszkáDepartment of Biochemistry, Comenius University in Bratislava, Faculty of Natural Sciences, Mlynská Dolina, Ilkovičova 6, 842 15 Bratislava, Slovakia.
Elodie VegaInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, 205 route de Narbonne, 31400 Toulouse, France.
Souhir AbidChemistry Department, College of Science and Arts, Jouf University, Al Qurayyat, Saudi Arabia.
Anna GrzegorzewiczMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523-1682, United States.
Mary JacksonMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523-1682, United States.ORCID 0000-0002-9212-0258
Antonio PeixotoInstitut de Pharmacologie et de Biologie Structurale, IPBS, Université de Toulouse, CNRS, UPS, 205 route de Narbonne, 31400 Toulouse, France.
Jana KordulákováDepartment of Biochemistry, Comenius University in Bratislava, Faculty of Natural Sciences, Mlynská Dolina, Ilkovičova 6, 842 15 Bratislava, Slovakia.ORCID 0000-0003-2834-0165
Maria Rosalia PascaDepartment of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, via Ferrata 9, 27100 Pavia, Italy.ORCID 0000-0002-8906-4937
Christian LherbetITAV, Université de Toulouse, CNRS USR3505, UPS, 1 place Pierre Potier, 31106 Toulouse Cedex 1, France.
Stefan ChassaingITAV, Université de Toulouse, CNRS USR3505, UPS, 1 place Pierre Potier, 31106 Toulouse Cedex 1, France.ORCID 0000-0001-5842-5288
Centre National de la Recherche Scientifique · FRUniversity of Pavia · ITComenius University Bratislava · SKColorado State University · USUniversity of Sfax · TN

Funding

Mechanisms of Susceptibility and Resistance of Mycobacterium tuberculosis to Isoxyl and ThiacetazoneR21AI130929 · NIAID · COLORADO STATE UNIVERSITY · PI JACKSON, MARY · 2017 to 2018
$442k
NIAID NIH HHS R21 AI130929
6 · The paper itself

Abstract

A novel coumarin-based molecule, designed as a fluorescent surrogate of a thiacetazone-derived antitubercular agent, was quickly and easily synthesized from readily available starting materials. This small molecule, coined

Indexed as

LepidopteraMycobacterium tuberculosisThioacetazoneAnimalsAntitubercular AgentsCoumarinsAntitubercular AgentsCoumarinsThioacetazonecoumarinfluorescenceHadAMycobacterium tuberculosisthiacetazone

Identifiers

PMID33617235
PMCPMC8022203
OpenAlexW3129641179

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.