ArticleThe New phytologist2021
Discrete bHLH transcription factors play functionally overlapping roles in pigmentation patterning in flowers of Antirrhinum majus.
Article in The New phytologist, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 66 citations in OpenAlex.
- A 32-bp deletion inHorticulture research · 2026Article
- Genome sequence of the ornamental plant Digitalis purpurea reveals the molecular basis of flower color and morphology variation.BMC genomics · 2026Article
- Convergence and parallelism in the evolution of plant metabolism.Journal of integrative plant biology · 2026Review
- Harnessing Bulk-Segregant Mapping to Identify Trait-Associated Genes in the Allopolyploid Model Plant Nicotiana benthamiana.Plant biotechnology journal · 2026Article
- Identification and characterization of the gene OvANS associated with purple flower in Orychophragmus violaceus.BMC plant biology · 2025Article
- Glycyrrhiza, a commonly used medicinal herb: Review of species classification, pharmacology, active ingredient biosynthesis, and synthetic biology.Journal of advanced research · 2025Review
- Three bilberry bHLHs of subgroup IIIf play divergent roles in fruit anthocyanin and flavonoid biosynthesis.Scientific reports · 2025Article
- Unstable anthocyanin pigmentation in Streptocarpus sect. Saintpaulia (African violet) is due to transcriptional selectivity of a single MYB gene.The New phytologist · 2025Article
- Molecular Control of Flower Colour Change in Angiosperms.Plants (Basel, Switzerland) · 2025Review
- A witches' broom phytoplasma effector induces stunting by stabilizing a bHLH transcription factor in Ziziphus jujuba plants.The New phytologist · 2025Article
- Comprehensive genomic analysis of SmbHLH genes and the role of SmbHLH93 in eggplant anthocyanin biosynthesis.Plant cell reports · 2025Article
- Regulation of Flavonoid Biosynthesis by the MYB-bHLH-WDR (MBW) Complex in Plants and Its Specific Features in Cereals.International journal of molecular sciences · 2025Review
- The StbHLH47 transcription factor negatively regulates drought tolerance in potato (Solanum tuberosum L.).BMC plant biology · 2025Article
- Evolution and development of complex floral displays.Development (Cambridge, England) · 2024Review
- Allelic variation of BBX24 is a dominant determinant controlling red coloration and dwarfism in pear.Plant biotechnology journal · 2024Article
- Evolutionary studies of the bHLH transcription factors belonging to MBW complex: their role in seed development.Annals of botany · 2023Review
- Vaccinium as a comparative system for understanding of complex flavonoid accumulation profiles and regulation in fruit.Plant physiology · 2023Article
- The combination of DNA methylation and positive regulation of anthocyanin biosynthesis by MYB and bHLH transcription factors contributes to the petal blotch formation in Xibei tree peony.Horticulture research · 2023Article
- Flavonoids - flowers, fruit, forage and the future.Journal of the Royal Society of New Zealand · 2023Review
- The Amsterdam petunia germplasm collection: A tool in plant science.Frontiers in plant science · 2023Review
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Authors and funding
8 authors at 3 institutions in 2 countries.
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Abstract
Floral pigmentation patterning is important for pollinator attraction as well as aesthetic appeal. Patterning of anthocyanin accumulation is frequently associated with variation in activity of the Myb, bHLH and WDR transcription factor complex (MBW) that regulates anthocyanin biosynthesis. Investigation of two classic mutants in Antirrhinum majus, mutabilis and incolorata I, showed they affect a gene encoding a bHLH protein belonging to subclade bHLH-2. The previously characterised gene, Delila, which encodes a bHLH-1 protein, has a bicoloured mutant phenotype, with residual lobe-specific pigmentation conferred by Incolorata I. Both Incolorata I and Delila induce expression of the anthocyanin biosynthetic gene DFR. Rosea 1 (Myb) and WDR1 proteins compete for interaction with Delila, but interact positively to promote Incolorata I activity. Delila positively regulates Incolorata I and WDR1 expression. Hierarchical regulation can explain the bicoloured patterning of delila mutants, through effects on both regulatory gene expression and the activity of promoters of biosynthetic genes like DFR that mediate MBW regulation. bHLH-1 and bHLH-2 proteins contribute to establishing patterns of pigment distribution in A. majus flowers in two ways: through functional redundancy in regulating anthocyanin biosynthetic gene expression, and through differences between the proteins in their ability to regulate genes encoding transcription factors.
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