ArticleThe international journal of cardiovascular imaging2021
The corrected left ventricular ejection fraction: a potential new measure of ventricular function.
Article in The international journal of cardiovascular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- A data-driven computational methodology for assessing ventricular ablation procedures.Biomechanics and modeling in mechanobiology · 2026Article
- Myocardial active strain energy density and contractance: novel prognostic tools for left ventricular function and cardiovascular risk.European heart journal. Imaging methods and practice · 2025Review
- Associations of Left Atrial Volume Index to Left Ventricular Ejection Fraction Ratio with Clinical Outcomes in Transthyretin Cardiac Amyloidosis.Journal of cardiovascular development and disease · 2024Article
- Global longitudinal active strain energy density (GLASED): a powerful prognostic marker in a community-based cohort.European heart journal. Cardiovascular Imaging · 2024Article
- Global longitudinal active strain energy density (GLASED): age and sex differences between young and veteran athletes.Echo research and practice · 2024Article
- [Using CT to Evaluate Cardiac Function].Journal of the Korean Society of Radiology · 2024Review
- A Holistic View of Advanced Heart Failure.Life (Basel, Switzerland) · 2022Review
- Left ventricular active strain energy density is a promising new measure of systolic function.Scientific reports · 2022Article
- Left ventricular ejection fraction: how to improve an established index?The international journal of cardiovascular imaging · 2021Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Left ventricular ejection fraction (LVEF) has a limited role in predicting outlook in heart diseases including heart failure. We quantified the independent geometric factors that determine LVEF using cardiac MRI and sought to provide an improved measure of ventricular function by adjusting for such independent variables. A mathematical model was used to analyse the independent effects of structural variables and myocardial shortening on LVEF. These results informed analysis of cardiac MRI data from 183 patients (53 idiopathic dilated cardiomyopathy (DCM), 36 amyloidosis, 55 hypertensives and 39 healthy controls). Left ventricular volumes, LVEF, wall thickness, internal dimensions and longitudinal and midwall fractional shortening were measured. The modelling demonstrated LVEF increased in a curvilinear manner with increasing mFS and longitudinal shortening and wall thickness but decreased with increasing internal diameter. Controls in the clinical cohort had a mean LVEF 64 ± 7%, hypertensives 66 ± 8%, amyloid 49 ± 16% and DCM 30 ± 11%. The mean end-diastolic wall thickness in controls was 8 ± 1 mm, DCM 8 ± 1 mm, hypertensives 11 ± 3 mm and amyloid 14 ± 3 mm, P < 0.0001). LVEF correlated with absolute wall thickening relative to ventricular size (R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.