ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2021
Superficial macular vessel density in eyes with mild, moderate, and severe primary open-angle glaucoma.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Relationship Between Macular Perfusion Density and Central Visual Field Loss in Primary Open Angle Glaucoma.Journal of glaucoma · 2026Article
- The relationship of macular vessel density and foveal avascular zone with pulse wave velocity and central blood pressure in healthy adults: Persian cohort study.International journal of retina and vitreous · 2024Article
- Effect of Different Postures on Intraocular Pressure in Open-Angle Glaucoma.Ophthalmology and therapy · 2024Article
- Cytomegalovirus-positive Posner-Schlossman syndrome: to compare differences in retinal vessel area density between the affected and non-affected eye using optical coherence tomography angiography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Observational
- Early changes of ganglion cell-inner plexiform layer thickness and macular microvasculature in Posner-Schlossman syndrome: a binocular control study by OCTA.Frontiers in medicine · 2023Article
- Quantitative Measurements of Vessel Density and Blood Flow Areas Primary Angle Closure Diseases: A Study of Optical Coherence Tomography Angiography.Journal of clinical medicine · 2022Article
- Article
- Quantification of vascular morphology in optical coherence tomography angiography in primary open angle glaucoma.Advances in ophthalmology practice and researchArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeThe aim of this study is to report changes in and associations of macular vessel density (VD) and perfusion density (PD) using optical coherence tomography angiography (OCTA) in mild, moderate, and severe open-angle glaucoma.
methodsOne hundred thirty-three patients with open-angle glaucoma (133 eyes: 47 mild, 33 moderate, and 53 severe glaucoma) and 73 normal subjects (right eyes) were included in this cross-sectional study. All subjects underwent Cirrus OCTA measurements. One-way analysis of variance (ANOVA) was used to compare macular VD and PD between the controls and mild, moderate, and severe glaucoma groups. Multiple linear regression was performed with OCTA parameters as the predicted variable and age, gender, spherical equivalent (SE), intraocular pressure (IOP), mean deviation (MD), signal strength (SS), and mean macular ganglion cell-inner plexiform layer (mGCIPL) thickness as the predictor variables.
resultsThe total area of VD showed significant differences between the controls vs. mild (p < 0.001) and moderate vs. severe glaucoma (p = 0.003); no significant difference was found between mild and moderate glaucoma (p = 1.000). Macular VD was associated with age (β = -0.02, p = 0.003), MD (β = 0.04, p = 0.001), SS (β = 1.43, p < 0.001), and mGCIPL thickness (β = 0.04, p = 0.002) but not with gender, SE, and IOP (all p > 0.05).
conclusionsMacular microcirculation declined significantly in mild and severe glaucoma. No significant difference was found between mild and moderate glaucoma. Decrease macular VD was independently associated with age, severe MD, lower SS, and thinner mGCIPL thickness.
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