ArticleEuropean journal of applied physiology2021
Impact of isometric and concentric resistance exercise on pain and fatigue in fibromyalgia.
Article in European journal of applied physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03778385 (Exercise Specificity and Endogenous Pain Modulation), which is not on this map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Exercise Specificity and Endogenous Pain Modulation
Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Comparing physical activity practice, pain and psychological characteristics in individuals with fibromyalgia and individuals with low back pain.Chiropractic & manual therapies · 2026Article
- Combined aerobic exercise and photobiomodulation for pain and other symptoms in fibromyalgia: study protocol.Pain management · 2025Article
- Quantitative Sensory Testing in Fibromyalgia Syndrome: A Scoping Review.Biomedicines · 2025Review
- Review
- A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System.Biomedicines · 2025Review
- Synergistic effect of Majoon-e-Suranjaan and isometric exercises in improving rheumatoid arthritis.American journal of translational research · 2025Article
- Through the Lens of Movement-Evoked Pain: A Theoretical Framework of the "Pain-Movement Interface" to Guide Research and Clinical Care for Musculoskeletal Pain Conditions.The journal of pain · 2024Review
- Localized Pain and Fatigue During Recovery From Submaximal Resistance Exercise in People With Fibromyalgia.Physical therapy · 2023Observational
- Cervical Joint Position Sense and Its Correlations with Postural Stability in Subjects with Fibromyalgia Syndrome.Life (Basel, Switzerland) · 2022Article
- Virtual Reality-Based Therapy Reduces the Disabling Impact of Fibromyalgia Syndrome in Women: Systematic Review with Meta-Analysis of Randomized Controlled Trials.Journal of personalized medicine · 2021Review
- Fitness levels do not explain greater performance fatigability of the upper extremity in fibromyalgia.European journal of applied physiology · 2021Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe aim of this study was to determine the local and systemic effects of isometric and concentric muscle contractions on experimental pain and performance fatigability in people with and without fibromyalgia.
methodsForty-seven fibromyalgia (FM: 51.3 ± 12.3 year) and 47 control (CON: 52.5 ± 14.7 year) participants performed submaximal isometric and concentric exercise for 10 min with the right elbow flexors. Assessments before and after exercise included pressure pain thresholds (PPT) of the biceps and quadriceps, central pain summation, self-reported exercising arm and whole-body pain, and maximal voluntary isometric contraction (MVIC) of the right elbow flexors and left handgrip.
resultsPeople with FM experienced greater reductions in local fatigue (right elbow flexor MVIC: CON: - 4.0 ± 6.7%, FM: - 9.8 ± 13.8%; p = 0.013) and similar reductions in systemic fatigue (left handgrip MVIC: - 6.5 ± 10.2%; p < 0.001) as CON participants, which were not different by contraction type nor related to baseline clinical pain, perceived fatigue, or reported pain with exercise. Following exercise both groups reported an increase in PPTs at the biceps (pre: 205.5 ± 100.3 kPa, post: 219.0 ± 109.3 kPa, p = 0.004) only and a decrease in central pain summation (pre: 6.8 ± 2.9, post: 6.5 ± 2.9; p = 0.013). FM reported greater exercising arm pain following exercise (CON: 0.7 ± 1.3, FM: 2.9 ± 2.3; p < 0.001), and both groups reported greater arm pain following concentric (isometric: 1.4 ± 2.0, concentric: 2.2 ± 2.9; p = 0.001) than isometric exercise. Neither group reported an increase in whole-body pain following exercise.
conclusionPeople with FM experienced greater performance fatigability in the exercising muscle compared to CON that was not related to central mechanisms of fatigue or pain. These results suggest changes in performance fatigability in FM may be due to differences occurring at the muscular level. TRIAL REGISTRATION #: NCT #: NCT03778385, December 19, 2018, retrospectively registered. IRB#: HR-3035.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.