Evidence map›Paper›PMID 33616748›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2021

Effects of hyaluronic acid-collagen nanofibers on early wound healing in vocal cord trauma.

Elif Elibol, Yavuz Fuat Yılmaz, Adnan Ünal, Müge Ozcan, Nurcan Yurtsever Kum, Rauf Oğuzhan Kum, Sezer Kulaçoğlu

Abstract read
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In one paragraph

Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Injection laryngoplasty with hyaluronic acid for glottal insufficiency in unilateral vocal fold paralysis: a systematic review of the literature.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Pooled it
  2. Review
  3. Exploring the anti-inflammatory potential of topical hyaluronic acid for vocal fold injury in a rat model.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  4. Biodegradable dexamethasone polymer capsule for long-term release.The Korean journal of chemical engineering · 2023
    Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Elif ElibolDepartment of Ear, Nose and Throat Diseases, Ankara City Hospital, Üniversiteler Mahallesi 1604. Cadde No: 9 Çankaya, Ankara, Turkey. drelifzer@yahoo.com.ORCID http://orcid.org/0000-0001-6563-1776
Yavuz Fuat YılmazDepartment of Ear, Nose and Throat Diseases, Gülhane Training and Research Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0003-0668-3263
Adnan Ünal, Ankara, Turkey.ORCID http://orcid.org/0000-0003-4015-0727
Müge Ozcan, Ankara, Turkey.ORCID http://orcid.org/0000-0003-2384-3564
Nurcan Yurtsever KumDepartment of Ear, Nose and Throat Diseases, Ankara City Hospital, Üniversiteler Mahallesi 1604. Cadde No: 9 Çankaya, Ankara, Turkey.ORCID http://orcid.org/0000-0002-7528-8294
Rauf Oğuzhan KumDepartment of Ear, Nose and Throat Diseases, Ankara City Hospital, Üniversiteler Mahallesi 1604. Cadde No: 9 Çankaya, Ankara, Turkey.ORCID http://orcid.org/0000-0002-9639-0204
Sezer KulaçoğluDepartment of Pathology, Ankara City Hospital, Ankara, Turkey.ORCID http://orcid.org/0000-0003-3288-2039
Çankaya University · TRGülhane Askerî Tıp Akademisi · TRMemorial Ankara Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVocal cord scarring is the most crucial obstacle in voice quality after surgery. This study aimed to evaluate the effectiveness of hyaluronic acid (HA)-collagen nanofibers on the healing of vocal cords after surgical trauma.

methodRight vocal cords of 12 New Zealand white rabbits were traumatized, and the experimental group was received 1.08 mg/75 ml topical HA-collagen nanofiber (Gelfix

resultThe 7th-day H&E staining evaluation revealed pink, dense, and thin collagen fibers. Besides, the collagen content was scattered and irregular in the experimental group. The 21st-day assessment showed that the collagen bundles in the granulation tissue were almost with the same formation in both of the groups. Masson Trichrome staining on the 7

conclusionHA-collagen nanofiber can be used in diseases that impair voice quality due to the thickening of the lamina propria layer in the vocal cord and impaired viscoelasticity due to fibrosis after tissue trauma.

Indexed as

NanofibersVocal CordsAnimalsCollagenHyaluronic AcidRabbitsWound HealingCollagenHyaluronic AcidCollagenNanofibersTraumaVocal cordsWound healing

Identifiers

PMID33616748
OpenAlexW3130325320

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.