ArticleThe Plant cell2021
The PIF1-miR408-PLANTACYANIN repression cascade regulates light-dependent seed germination.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 70 citations in OpenAlex.
- CML20 integrates phytochrome and calcium signaling pathways to optimize seed germination under abiotic stress.Nature communications · 2026Article
- Light-Controlled Seed Germination: Molecular Integration With Environmental Signals.Plant, cell & environment · 2026Review
- The genetic architecture of leaf vein density and its importance for photosynthesis in maize.The New phytologist · 2026Article
- The TaDof-2D-miR1832-TaP450-7A module regulates low-temperature-induced seed dormancy release in wheat.Plant communications · 2026Article
- Holistic overview of regulatory networks governing seed dormancy and germination in plants.Science China. Life sciences · 2026Review
- Transcriptomic and physiological effects of superabsorbent polymer seed coating on maize under drought stress.Frontiers in plant science · 2026Article
- Light interacts with mechanical stress to regulate the seed-to-seedling transition.Stress biology · 2025Review
- PagMIR166c targets PagECH2 to regulate cambial differentiation into secondary xylem, cell expansion, and lignin deposition via different auxin signaling pathways in poplar stems.The New phytologist · 2025Article
- The Proteomic and Peptidomic Response of Wheat (Plants (Basel, Switzerland) · 2025Article
- Regulation of seed germination: ROS, epigenetic, and hormonal aspects.Journal of advanced research · 2025Review
- Article
- MicroRNA analysis reveals 2 modules that antagonistically regulate xylem tracheary element development in Arabidopsis.The Plant cell · 2024Article
- The microRNA408-plantacyanin module balances plant growth and drought resistance by regulating reactive oxygen species homeostasis in guard cells.The Plant cell · 2024Article
- An epigenetically mediated double negative cascade from EFD to HB21 regulates anther development.Nature communications · 2024Article
- Comprehensive dissection of variation and accumulation of free amino acids in tea accessions.Horticulture research · 2024Article
- Riboflavin mediates m6A modification targeted by miR408, promoting early somatic embryogenesis in longan.Plant physiology · 2023Article
- microRNA408 and its encoded peptide regulate sulfur assimilation and arsenic stress response in Arabidopsis.Plant physiology · 2023Article
- Loss of OPT3 function decreases phloem copper levels and impairs crosstalk between copper and iron homeostasis and shoot-to-root signaling in Arabidopsis thaliana.The Plant cell · 2023Article
- Delineating the tissue-mediated drought stress governed tuning of conserved miR408 and its targets in rice.Functional & integrative genomics · 2023Article
- Genome-Wide Association Study for Seed Dormancy Using Re-Sequenced Germplasm under Multiple Conditions in Rice.International journal of molecular sciences · 2023Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light-dependent seed germination is a vital process for many seed plants. A decisive event in light-induced germination is degradation of the central repressor PHYTOCHROME INTERACTING FACTOR 1 (PIF1). The balance between gibberellic acid (GA) and abscisic acid (ABA) helps to control germination. However, the cellular mechanisms linking PIF1 turnover to hormonal balancing remain elusive. Here, employing far-red light-induced Arabidopsis thaliana seed germination as the experimental system, we identified PLANTACYANIN (PCY) as an inhibitor of germination. It is a blue copper protein associated with the vacuole that is both highly expressed in mature seeds and rapidly silenced during germination. Molecular analyses showed that PIF1 binds to the miR408 promoter and represses miR408 accumulation. This in turn posttranscriptionally modulates PCY abundance, forming the PIF1-miR408-PCY repression cascade for translating PIF1 turnover to PCY turnover during early germination. Genetic analysis, RNA-sequencing, and hormone quantification revealed that PCY is necessary and sufficient to maintain the PIF1-mediated seed transcriptome and the low-GA-high-ABA state. Furthermore, we found that PCY domain organization and regulation by miR408 are conserved features in seed plants. These results revealed a cellular mechanism whereby PIF1-relayed external light signals are converted through PCY turnover to internal hormonal profiles for controlling seed germination.
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