Evidence map›Paper›PMID 33616305›Full record

SynthesisAnnals of clinical and translational neurology2021

A meta-analysis of the global impact of the COVID-19 pandemic on stroke care & the Houston Experience.

Sujan T Reddy, Nikunj Satani, Jennifer E S Beauchamp, Sudhakar Selvaraj, Suja S Rajan, Mohammad H Rahbar, Amirali Tahanan, Sori Kim, Travis Holder, Xiaoqian Jiang and 5 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Annals of clinical and translational neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Time Metrics in Acute Ischemic Stroke Care During the Second and First Wave of COVID 19 Pandemic: A Tertiary Care Center Experience from South India.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Sujan T ReddyDepartment of Neurology, Mercy Hospital, Fort Smith, Arkansas, USA.ORCID 0000-0001-7454-114X
Nikunj SataniInstitute for Stroke and Cerebrovascular Diseases, McGovern Medical School, University of Texas Health Science Center at Houston, Texas, USA.
Jennifer E S BeauchampInstitute for Stroke and Cerebrovascular Diseases, McGovern Medical School, University of Texas Health Science Center at Houston, Texas, USA.
Sudhakar SelvarajLouis Faillace, MD, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, Texas, USA.
Suja S RajanInstitute for Stroke and Cerebrovascular Diseases, McGovern Medical School, University of Texas Health Science Center at Houston, Texas, USA.
Mohammad H RahbarBiostatistics/Epidemiology/Research Design Core, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Texas, USA.
Amirali TahananBiostatistics/Epidemiology/Research Design Core, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Texas, USA.
Sori KimBiostatistics/Epidemiology/Research Design Core, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Texas, USA.
Travis HolderTexas Medical Center Library, Houston, Texas, USA.
Xiaoqian JiangInstitute for Stroke and Cerebrovascular Diseases, McGovern Medical School, University of Texas Health Science Center at Houston, Texas, USA.
Luyao ChenInstitute for Stroke and Cerebrovascular Diseases, McGovern Medical School, University of Texas Health Science Center at Houston, Texas, USA.
Haris KamalDepartment of Neurosurgery, Westchester Medical Center, New York, USA.
Hari Kishan R IndupuruInstitute for Stroke and Cerebrovascular Diseases, McGovern Medical School, University of Texas Health Science Center at Houston, Texas, USA.
Tzu-Ching WuInstitute for Stroke and Cerebrovascular Diseases, McGovern Medical School, University of Texas Health Science Center at Houston, Texas, USA.
Sean I SavitzInstitute for Stroke and Cerebrovascular Diseases, McGovern Medical School, University of Texas Health Science Center at Houston, Texas, USA.
The University of Texas Health Science Center at Houston · USMercy Medical Center · USTexas Medical Center · USThe University of Texas Health Science Center · USWestchester Medical Center · US

Funding

Convalescent Plasma to Limit Coronavirus Associated ComplicationsUL1TR003167 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARP, DANIEL D, MCPHERSON, DAVID D · 2019 to 2023
$45.3M
NCATS NIH HHS UL1 TR003167
6 · The paper itself

Abstract

objectiveTo review the global impact of the COVID-19 pandemic on stroke care-metrics and report data from a health system in Houston.

methodsWe performed a meta-analysis of the published literature reporting stroke admissions, intracerebral hemorrhage (ICH) cases, number of thrombolysis (tPA) and thrombectomy (MT) cases, and time metrics (door to needle, DTN; and door to groin time, DTG) during the pandemic compared to prepandemic period. Within our hospital system, between January-June 2019 and January-June 2020, we compared the proportion of stroke admissions and door to tPA and MT times.

resultsA total of 32,640 stroke admissions from 29 studies were assessed. Compared to prepandemic period, the mean ratio of stroke admissions during the pandemic was 70.78% [95% CI, 65.02%, 76.54%], ICH cases was 83.10% [95% CI, 71.01%, 95.17%], tPA cases was 81.74% [95% CI, 72.33%, 91.16%], and MT cases was 88.63% [95% CI, 74.12%, 103.13%], whereas DTN time was 104.48% [95% CI, 95.52%, 113.44%] and DTG was 104.30% [95% CI, 81.99%, 126.61%]. In Houston, a total of 4808 cases were assessed. There was an initial drop of ~30% in cases at the pandemic onset. Compared to 2019, there was a significant reduction in mild strokes (NIHSS 1-5) [N (%), 891 (43) vs 635 (40), P = 0.02]. There were similar mean (SD) (mins) DTN [44 (17) vs 42 (17), P = 0.14] but significantly prolonged DTG times [94 (15) vs 85 (20), P = 0.005] in 2020.

interpretationThe COVID-19 pandemic led to a global reduction in stroke admissions and treatment interventions and prolonged treatment time metrics.

Indexed as

Brain IschemiaCOVID-19Fibrinolytic AgentsHumansPandemicsPatient AdmissionStrokeTexasThrombectomyThrombolytic TherapyFibrinolytic Agents

Identifiers

PMID33616305
PMCPMC8014129
OpenAlexW3132622298

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.