Evidence map›Paper›PMID 33616271›Full record

ArticleAngewandte Chemie (International ed. in English)2021

Controlled Ligand Exchange Between Ruthenium Organometallic Cofactor Precursors and a Naïve Protein Scaffold Generates Artificial Metalloenzymes Catalysing Transfer Hydrogenation.

George S Biggs, Oskar James Klein, Sarah L Maslen, J Mark Skehel, Trevor J Rutherford, Stefan M V Freund, Florian Hollfelder, Sally R Boss, Paul D Barker

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Early Transition Metal-Based Antitumor Complexes.Chemistry, an Asian journal · 2026
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

George S BiggsDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.ORCID 0000-0001-6526-9236
Oskar James KleinDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.ORCID 0000-0003-2213-8003
Sarah L MaslenMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.ORCID 0000-0002-0261-2866
J Mark SkehelMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.ORCID 0000-0002-2432-0901
Trevor J RutherfordMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.ORCID 0000-0001-7294-1668
Stefan M V FreundMRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.ORCID 0000-0002-7031-9872
Florian HollfelderDepartment of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, UK.ORCID 0000-0002-1367-6312
Sally R BossDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.ORCID 0000-0002-6194-1889
Paul D BarkerDepartment of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.ORCID 0000-0003-0094-0054
University of Cambridge · GBMRC Laboratory of Molecular Biology · GB

Funding

Medical Research Council MC_U105184326
6 · The paper itself

Abstract

Many natural metalloenzymes assemble from proteins and biosynthesised complexes, generating potent catalysts by changing metal coordination. Here we adopt the same strategy to generate artificial metalloenzymes (ArMs) using ligand exchange to unmask catalytic activity. By systematically testing Ru

Indexed as

CatalysisFluorineHydrogenationLigandsMagnetic Resonance SpectroscopyMetalloproteinsMolecular StructureOrganometallic CompoundsRutheniumFluorineLigandsMetalloproteinsOrganometallic CompoundsRutheniumdirect coordinationligand exchangemetalloenzymesrutheniumtransfer hydrogenation

Identifiers

PMID33616271
PMCPMC8251807
OpenAlexW3132886193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.