Evidence map›Paper›PMID 33616188›Full record

Trial reportAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine2021

Sex Moderates Treatment Effects of Integrated Collaborative Care for Comorbid Obesity and Depression: The RAINBOW RCT.

Nan Lv, Lan Xiao, Lisa G Rosas, Elizabeth M Venditti, Joshua M Smyth, Megan A Lewis, Mark B Snowden, Corina R Ronneberg, Leanne M Williams, Ben S Gerber and 3 more

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02246413 (RCT on Co-management of Obesity, Depression, and Elevated CVD Risk in Primary Care-- Engaging Self-regulation Targets to Understand the Mechanisms of Behavior Change and Improve Mood and Weight Outcomes), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02246413 nacompletednot on this map

RCT on Co-management of Obesity, Depression, and Elevated CVD Risk in Primary Care-- Engaging Self-regulation Targets to Understand the Mechanisms of Behavior Change and Improve Mood and Weight Outcomes

TypeinterventionalSponsorPalo Alto Medical FoundationRan2014 to 2018Enrolled409ConditionsDepression, ObesityArmsRAINBOW Intervention Program
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Nan LvInstitute of Health Research and Policy, University of Illinois at Chicago, Chicago, IL, USA.
Lan XiaoDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA.
Lisa G RosasDepartment of Epidemiology and Population Health, Stanford University, Palo Alto, CA, USA.
Elizabeth M VendittiDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Joshua M SmythDepartment of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA.
Megan A LewisCenter for Communication Science, RTI International, Seattle, WA, USA.
Mark B SnowdenDepartment of Psychiatry and Behavioral Sciences, School of Medicine, University of Washington, Seattle, WA, USA.
Corina R RonnebergInstitute of Health Research and Policy, University of Illinois at Chicago, Chicago, IL, USA.
Leanne M WilliamsDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Ben S GerberDivision of Academic Internal Medicine and Geriatrics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Olusola A AjiloreDepartment of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
Aashutos S PatelInstitute of Health Research and Policy, University of Illinois at Chicago, Chicago, IL, USA.
Jun MaInstitute of Health Research and Policy, University of Illinois at Chicago, Chicago, IL, USA.
University of Illinois Chicago · USStanford University · USPennsylvania State University · USRTI International · USUniversity of Pittsburgh · USUniversity of Washington · US

Funding

New York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8M
RCT on comanagement of obesity, depression, and elevated CVD risk in primary careR01HL119453 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MA, JUN · 2014 to 2018
$3.6M
Engaging self-regulation targets to understand the mechanisms of behavior change and improve mood and weight outcomesUH2HL132368 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MA, JUN, WILLIAMS, LEANNE · 2015 to 2017
$2.6M
NHLBI NIH HHS R01 HL119453NHLBI NIH HHS UH2 HL132368NIDDK NIH HHS P30 DK111022NIH HHS R01HL119453
6 · The paper itself

Abstract

backgroundSex influences health and related behaviors due to biological and psychosocial/socioeconomic factors. Assessing sex-specific responses to integrated treatment for comorbid obesity and depression could inform intervention targeting. PURPOSE: To test (a) whether sex moderates the effects of integrated collaborative care on weight and depression outcomes through 24 months and (b) whether treatment response at 6 months predicts 12 and 24 month outcomes by sex.

methodsSecondary data analyses on weight and depression severity (SCL-20) measured over 24 months among 409 adults with obesity and depression in the Research Aimed at Improving Both Mood and Weight trial.

resultsMen achieved significantly greater weight reductions in intervention versus usual care than women, whereas women achieved significantly greater percentage reductions in SCL-20 than men at both 12 and 24 months. In logistic models, at 80% specificity for correctly identifying participants not achieving clinically significant long-term outcomes, women who lost <3.0% weight and men who lost <4.1% weight at 6 months had ≥84% probability of not meeting 5% weight loss at 24 months. Similarly, at 80% specificity, women who reduced SCL-20 by <39.5% and men who reduced by <53.0% at 6 months had ≥82% probability of not meeting 50% decrease in SCL-20 at 24 months.

conclusionsSex modified the integrated treatment effects for obesity and depression. Sex-specific responses at 6 months predicted clinically significant weight loss and depression outcomes through 24 months. Based on early responses, interventions may need to be tailored to address sex-specific barriers and facilitators to achieving healthy weight and depression outcomes at later time points. CLINICAL

trial registrationNCT02246413 (https://clinicaltrials.gov/ct2/show/NCT02246413).

Indexed as

DepressionObesityAffectComorbidityFemaleHumansMaleWeight LossDepressionIntegrated collaborative careObesitySex differenceTreatment effect

Identifiers

PMID33616188
PMCPMC8601047
OpenAlexW3130344008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.