Evidence map›Paper›PMID 33616187›Full record

ArticleJournal of radiation research2021

Captopril reduces lung inflammation and accelerated senescence in response to thoracic radiation in mice.

Ognoon Mungunsukh, Jeffy George, Elizabeth A McCart, Andrew L Snow, Joseph J Mattapallil, Steven R Mog, Ronald Allan M Panganiban, David L Bolduc, W Bradley Rittase, Roxane M Bouten and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of radiation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Cardioprotective Role of Captopril: From Basic to Applied Investigations.International journal of molecular sciences · 2025
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ognoon MungunsukhDepartment of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Jeffy GeorgeDepartment of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Elizabeth A McCartDepartment of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Andrew L SnowDepartment of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Joseph J MattapallilDepartment of Microbiology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Steven R MogCenter for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD 20740, USA.
Ronald Allan M PanganibanDepartment of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
David L BolducScientific Research Department, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20889, USA.
W Bradley RittaseDepartment of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Roxane M BoutenDepartment of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Regina M DayDepartment of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
Uniformed Services University of the Health Sciences · USCenter for Food Safety and Applied Nutrition · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The lung is sensitive to radiation and exhibits several phases of injury, with an initial phase of radiation-induced pneumonitis followed by delayed and irreversible fibrosis. The angiotensin-converting enzyme inhibitor captopril has been demonstrated to mitigate radiation lung injury and to improve survival in animal models of thoracic irradiation, but the mechanism remains poorly understood. Here we investigated the effect of captopril on early inflammatory events in the lung in female CBA/J mice exposed to thoracic X-ray irradiation of 17-17.9 Gy (0.5-0.745 Gy min-1). For whole-body + thoracic irradiation, mice were exposed to 7.5 Gy (0.6 Gy min-1) total-body 60Co irradiation and 9.5 Gy thoracic irradiation. Captopril was administered orally (110 mg kg-1 day-1) in the drinking water, initiated 4 h through to150 days post-irradiation. Captopril treatment increased survival from thoracic irradiation to 75% at 150 days compared with 0% survival in vehicle-treated animals. Survival was characterized by a significant decrease in radiation-induced pneumonitis and fibrosis. Investigation of early inflammatory events showed that captopril significantly attenuated macrophage accumulation and decreased the synthesis of radiation-induced interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) pro-inflammatory cytokines in the lungs of irradiated mice. Suppression of IL-1β and TNF-α correlated with an increase of the anti-inflammatory cytokine IL-10 in the spleen with captopril treatment. We also found that captopril decreased markers for radiation-induced accelerated senescence in the lung tissue. Our data suggest that suppression of inflammation and senescence markers, combined with an increase of anti-inflammatory factors, are a part of the mechanism for captopril-induced survival in thoracic irradiated mice.

Indexed as

AgingAnimalsApoptosisBiomarkersCaptoprilCytokinesFemaleInflammation MediatorsLungMacrophages, AlveolarMiceMice, Inbred CBAPneumoniaPulmonary FibrosisSpleenSurvival AnalysisBiomarkersCaptoprilCytokinesInflammation Mediatorsangiotensin converting enzyme inhibitorinflammationionizing radiationmicepulmonary fibrosisthoracic irradiationtotal body irradiation

Identifiers

PMID33616187
PMCPMC7948861
OpenAlexW3131314374

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.