Evidence map›Paper›PMID 33615982›Full record

ReviewPlatelets2021

Platelets and viruses.

Silvio Antoniak, Nigel Mackman

Open access · greenAbstract readReview
In one paragraph

Review in Platelets, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. The role of platelets in sepsis: A review.Biomolecules & biomedicine · 2024
    Review
  9. Sepsis - it is all about the platelets.Frontiers in immunology · 2023
    Review
  10. Platelets interact with CD169Frontiers in immunology · 2023
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Silvio AntoniakUNC Blood Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0001-5523-825X
Nigel MackmanUNC Blood Research Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
University of North Carolina at Chapel Hill · US

Funding

Tissue factor-dependent coagulation in thrombosis and immune responsesR35HL155657 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Nigel Mackman · 2021 to 2026
$5.5M
Role of the Thrombin PAR-1 Pathway in Viral InfectionR01HL119523 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MACKMAN, NIGEL · 2013 to 2020
$3.0M
Inhibition of PAR2 as therapeutic approach to enhance anti-viral immune responsesR01HL142799 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ANTONIAK, SILVIO · 2018 to 2022
$1.9M
NHLBI NIH HHS R01 HL119523NHLBI NIH HHS R01 HL142799NHLBI NIH HHS R35 HL155657
6 · The paper itself

Abstract

Platelets play an essential role in maintaining vascular integrity after injury. In addition, platelets contribute to the immune response to pathogens. For instance, they express receptors that mediate binding of viruses, and toll-like receptors that activate the cell in response to pathogen-associated molecular patterns. Platelets can be beneficial and/or detrimental during viral infections. They reduce blood-borne viruses by engulfing the free virus and presenting the virus to neutrophils. However, platelets can also enhance inflammation and tissue injury during viral infections. Here, we discuss the roles of platelets in viral infection.

Indexed as

AnimalsBlood PlateletsCell CommunicationCOVID-19Dendritic CellsGene Expression RegulationHost-Pathogen InteractionsHumansImmunity, InnateLymphocytesNeutrophilsPlatelet ActivationProtein BindingReceptors, VirusToll-Like ReceptorsViral ProteinsReceptors, VirusToll-Like ReceptorsViral Proteinscoronavirusinfluenza A virusmyocarditisPlatelets

Identifiers

PMID33615982
PMCPMC7987802
OpenAlexW3132292376

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.