ArticleScandinavian journal of public health2021
Paternal prescription medication before conception: A retrospective cohort study of all births in Denmark 1997-2017.
Article in Scandinavian journal of public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Balsalazide Exposure During the Development of Fertilizing Sperm May Be Associated With Offspring Birth Defects.Inflammatory bowel diseases · 2022Article
- Preconception Antidiabetic Drugs in Men and Birth Defects in Offspring : A Nationwide Cohort Study.Annals of internal medicine · 2022Article
- Nervous system drugs taken by future fathers and birth defects in offspring: a prospective registry-based cohort study.BMJ open · 2022Article
- Variability Matters.International journal of environmental research and public health · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
aimTo study what medication fathers are being prescribed in the months preceding conception.
methodsA retrospective cohort study of Danish national registries, comprising all births in Denmark 1997-2017 (1.3 million births). Time trends and absolute levels of paternal prescription medication in the 6 months prior to conception were assessed. While all medications were examined (
resultsThe average number of prescriptions increased over the study period (from 0.75 prescriptions to 0.82 per birth). Polypharmacy (three or more prescriptions) increased from less than 8% to 10% of fathers. The use of pain medication, proton-pump inhibitors, selective serotonin reuptake inhibitors and some inhalants have all increased markedly over the last 20 years.
conclusionsPotential harm to the offspring done by paternal medication may present an increasing problem. As paternal medication exposure is increasing, examination of generational effects, such as major birth defects, is necessary.
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