Evidence map›Paper›PMID 33615888›Full record

ArticleAmerican journal of physiology. Renal physiology2021

Calcineurin A-α suppression drives nuclear factor-κB-mediated NADPH oxidase-2 upregulation.

Aswathy M Cheriyan, Adaku C Ume, Cynthia E Francis, Keyona N King, Valerie A Linck, Yun Bai, Hui Cai, Robert S Hoover, Heping P Ma, Jennifer L Gooch and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Aswathy M CheriyanDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University, Atlanta, Georgia.
Adaku C UmeDepartment of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, Ohio.ORCID 0000-0003-0219-8172
Cynthia E FrancisDepartment of Pharmaceutical Sciences, School of Pharmacy, Philadelphia College of Osteopathic Medicine, Suwanee, Georgia.
Keyona N KingDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University, Atlanta, Georgia.
Valerie A LinckDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University, Atlanta, Georgia.
Yun BaiDepartment of Pharmaceutical Sciences, School of Pharmacy, Philadelphia College of Osteopathic Medicine, Suwanee, Georgia.
Hui CaiDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University, Atlanta, Georgia.
Robert S HooverDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University, Atlanta, Georgia.
Heping P MaDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University, Atlanta, Georgia.
Jennifer L GoochDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University, Atlanta, Georgia.
Clintoria R WilliamsDivision of Nephrology, Department of Medicine, and Department of Physiology, Emory University, Atlanta, Georgia.
Emory University · USPhiladelphia College of Osteopathic Medicine · USWright State University · US

Funding

Role of Calcineurin Isoforms in Renal Regulation of Blood PressureR21DK119879 · NIDDK · WRIGHT STATE UNIVERSITY · PI WILLIAMS, CLINTORIA RICHARDS · 2018 to 2020
$630k
BLRD VA I01 BX000994HHS | National Institutes of Health (NIH) R21DK119879NIDDK NIH HHS R21 DK119879
6 · The paper itself

Abstract

Calcineurin inhibitors (CNIs) are vital immunosuppressive therapies in the management of inflammatory conditions. A long-term consequence is nephrotoxicity. In the kidneys, the primary, catalytic calcineurin (CnA) isoforms are CnAα and CnAβ. Although the renal phenotype of CnAα

Indexed as

AnimalsCalcineurinCalcineurin InhibitorsCell LineCyclosporineFibrosisImmunosuppressive AgentsKidneyKidney DiseasesMaleMiceMice, Inbred C57BLMice, KnockoutNADPH Oxidase 2NF-kappa BOxidative StressCalcineurinCalcineurin InhibitorsCybb protein, mouseCyclosporineImmunosuppressive AgentsNADPH Oxidase 2NF-kappa BReactive Oxygen Speciescalcineurin inhibitorscalcineurin isoformsNADPH oxidaseNF-κBoxidative stress

Identifiers

PMID33615888
PMCPMC8424558
OpenAlexW3129874869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.