Evidence map›Paper›PMID 33615427›Full record

SynthesisPharmacoEconomics2021

Utility Decrements Associated with Adult Overweight and Obesity in Australia: A Systematic Review and Meta-Analysis.

Joseph Carrello, Alison Hayes, Anagha Killedar, Amy Von Huben, Louise A Baur, Stavros Petrou, Thomas Lung

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in PharmacoEconomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joseph CarrelloSchool of Public Health, Edward Ford Building, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, 2006, Australia. jcar6556@uni.sydney.edu.au.ORCID http://orcid.org/0000-0001-6423-6555
Alison HayesSchool of Public Health, Edward Ford Building, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, 2006, Australia.
Anagha KilledarSchool of Public Health, Edward Ford Building, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, 2006, Australia.
Amy Von HubenSchool of Public Health, Edward Ford Building, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, 2006, Australia.
Louise A BaurSchool of Public Health, Edward Ford Building, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, 2006, Australia.
Stavros PetrouNuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Oxford, UK.
Thomas LungSchool of Public Health, Edward Ford Building, Faculty of Medicine and Health, University of Sydney, Camperdown, NSW, 2006, Australia.

Funding

Medical Research Council G0501681
6 · The paper itself

Abstract

objectiveThe aim was to conduct a systematic review and meta-analysis of health state utility decrements associated with overweight and obesity in adults 18 years and over, for use in modelled economic evaluations in Australia.

methodsA systematic review was conducted in nine databases to identify studies that reported health state utility values by weight status. Random-effects meta-analysis was used to synthesise average utility decrements (from healthy weight) associated with overweight, all obesity and obesity classes 1, 2 and 3. Heterogeneity surrounding utility decrements was assessed via sub-group analysis, random-effects meta-regression and sensitivity analyses.

resultsTwelve studies were found for which data were used to synthesise utility decrements, estimated as overweight = 0.020 (95% confidence interval 0.010-0.030), all obesity = 0.055 (0.034-0.076), obesity class 1 = 0.047 (0.017-0.077), class 2 = 0.072 (0.028-0.116) and class 3 = 0.084 (0.039-0.130). There was considerable heterogeneity in our results, which could be accounted for by the different ages and utility instruments used in the contributing studies.

conclusionsOur results demonstrate that elevated weight status is associated with small but statistically significant reductions in utility compared with healthy weight, which will result in reduced quality-adjusted life years when extrapolated across time and used in economic evaluations.

Indexed as

ObesityOverweightAdolescentAdultAustraliaHealth StatusHumansQuality-Adjusted Life Years

Identifiers

PMID33615427

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.