Evidence map›Paper›PMID 33615415›Full record

ArticleEuropean journal of nutrition2021

Plant food intake is associated with lower cadmium body burden in middle-aged adults.

Kristine K Dennis, Suzanne E Judd, Jessica A Alvarez, Ka Kahe, Dean P Jones, Terryl J Hartman

Abstract read
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In one paragraph

Article in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Kristine K DennisNutrition and Health Sciences, Laney Graduate School, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-2753-7329
Suzanne E JuddSchool of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Jessica A AlvarezNutrition and Health Sciences, Laney Graduate School, Emory University, Atlanta, GA, USA.
Ka KaheEpidemiology and Obstetrics and Gynecology, Columbia University Irving Medical Center, New York City, NY, USA.
Dean P JonesNutrition and Health Sciences, Laney Graduate School, Emory University, Atlanta, GA, USA.
Terryl J HartmanNutrition and Health Sciences, Laney Graduate School, Emory University, Atlanta, GA, USA. tjhartm@emory.edu.
Emory University · USColumbia University Irving Medical Center · USUniversity of Alabama at Birmingham · US

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Nutrition Sciences and HealthT32DK007734 · NIDDK · EMORY UNIVERSITY · PI RAMAKRISHNAN, USHA · 1997 to 2016
$2.5M
Trace element levels and risk of strokeR01ES021735 · NIEHS · TRUSTEES OF INDIANA UNIVERSITY · PI KAHE, KA, MCCLURE, LESLIE AIN · 2012 to 2016
$2.3M
Health benefits of plant-based diets: effects of dietary phytochelatins on toxic metal absorptionF31ES030980 · NIEHS · EMORY UNIVERSITY · PI DENNIS, KRISTINE · 2019 to 2020
$74k
NIDDK NIH HHS T32 DK007734NIEHS NIH HHS F31 ES030980NIEHS NIH HHS R01 ES021735NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

purposeDietary intake is a primary source of cadmium (Cd) exposure in the non-smoking population. Plant foods containing metal-binding plant compounds such as polyphenols, phytates, and phytochelatins may reduce Cd bioavailability and result in lower Cd body burden. In this study, we investigated the association between plant food intake and urinary creatinine-adjusted Cd (uCd), a well-established marker of Cd body burden.

methodsParticipants were from a cross-sectional sample of 1901 adults in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Dietary intake was assessed with a food frequency questionnaire. We created a 12-point plant food score (PFS) based on reported intake across seven categories (fruits, vegetables, legumes, nuts/seeds, whole grains, tea, and wine). Higher scores indicated higher consumption and diversity of plant food intake. Multivariable linear regression models were used to estimate the association between PFS and uCd. Due to the influence of age and smoking on Cd status, stratified analyses were conducted.

resultsMean PFS was 5.4 (SD 2.2) and mean uCd was 0.53 µg/g creatinine (SD 0.39). In adjusted models, PFS was not associated with uCd (p > 0.05). In stratified analyses, PFS was inversely associated with uCd (p = 0.047) with a 1-point higher PFS associated with 0.018 µg/g lower uCd among middle-aged (45-59) adults. No significant association was observed between PFS and uCd in older (≥ 60) adults. The association of PFS and uCd did not differ by smoking status.

conclusionOur findings suggest higher plant food intake is associated with lower Cd body burden in middle-aged but not older adults.

Indexed as

CadmiumDietAgedBody BurdenCross-Sectional StudiesEatingHumansMiddle AgedCadmiumDietEpidemiologyMetal-bindingPlant food scoreToxic metals

Identifiers

PMID33615415
OpenAlexW3131877919

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.