ArticleAmerican journal of epidemiology2021
Propensity Score Weighting and Trimming Strategies for Reducing Variance and Bias of Treatment Effect Estimates: A Simulation Study.
Article in American journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
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Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Use of sensitivity analyses to assess uncontrolled confounding from unmeasured variables in observational, active comparator pharmacoepidemiologic studies: a systematic review.American journal of epidemiology · 2025Pooled it
- Combined Conventional Synthetic Disease Modifying Therapy vs. Infliximab for Rheumatoid Arthritis: Emulating a Randomized Trial in Observational Data.Clinical pharmacology and therapeutics · 2022Trial
- Young adult polysubstance use trajectories and later non-prescribed opioid use and drug use disorder symptoms: A propensity score-matched analysis.Drug and alcohol dependence reports · 2026Article
- Time to Insulin Initiation Among Patients With Type 2 Diabetes Treated With Second-Line Antidiabetic Drugs.Diabetes, obesity & metabolism · 2026Article
- Comparative Effectiveness of Sacubitril/Valsartan Versus Sodium-Glucose Cotransporter 2 Inhibitors among Patients with Heart Failure with Reduced Ejection Fraction with or without Diabetes: A Cohort Study.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2026Article
- Impact of empiric potassium supplementation on mortality, sudden cardiac arrest and stroke in furosemide initiators.British journal of clinical pharmacology · 2026Article
- Active surveillance of drug safety in healthcare data: Sequential monitoring of bacterial and serious urinary tract infection risk in sodium-glucose cotransporter 2 inhibitor users.British journal of clinical pharmacology · 2026Article
- Choosing Covariate Balancing Methods for Causal Inference: Practical Insights From a Simulation Study.Statistics in medicine · 2026Article
- Impact of multimodal analgesia using intravenous non-opioid agents on immediate postoperative rescue analgesic use following minor general surgery: a retrospective study.The Korean journal of pain · 2026Article
- Ventricular Arrhythmia and Sudden Death Risk With Concomitant Antipsychotic and SSRI Use.JAMA network open · 2026Article
- Sexual Dysfunction in Male Patients After Initiating Treatment with Antidepressants.Drug safety · 2026Article
- The effect of time to surgery on clinical outcomes and hospitalization costs in older adults with femoral shaft fractures: A nationwide retrospective cohort study in Japan.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Tumor stage and treatment outcomes in external auditory canal SCC: a multicenter cohort study.International journal of surgery (London, England) · 2026Article
- Article
- Cost impact of in-patient specialist palliative care: A retrospective economic study of administrative end-of-life hospital costs across 7 years in Switzerland.Palliative care and social practice · 2026Article
- Comparative Gastrointestinal Safety of Dulaglutide, Semaglutide, and Tirzepatide in Adults With Type 2 Diabetes.Annals of internal medicine · 2026Article
- A comparison of causal inference methods for evaluating multiple treatment groups.Journal of nonparametric statistics · 2025Article
- Robotic surgery enhances patients' survival in rectal cancer: a propensity score-weighted multicenter cohort study.Surgical endoscopy · 2025Article
- First-Trimester mRNA COVID-19 Vaccination and Risk of Major Congenital Anomalies.JAMA network open · 2025Article
- Instrumental variable approaches for estimating time-varying treatment effects in comparative effectiveness research.BMC medical research methodology · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
To extend previous simulations on the performance of propensity score (PS) weighting and trimming methods to settings without and with unmeasured confounding, Poisson outcomes, and various strengths of treatment prediction (PS c statistic), we simulated studies with a binary intended treatment T as a function of 4 measured covariates. We mimicked treatment withheld and last-resort treatment by adding 2 "unmeasured" dichotomous factors that directed treatment to change for some patients in both tails of the PS distribution. The number of outcomes Y was simulated as a Poisson function of T and confounders. We estimated the PS as a function of measured covariates and trimmed the tails of the PS distribution using 3 strategies ("Crump," "Stürmer," and "Walker"). After trimming and reestimation, we used alternative PS weights to estimate the treatment effect (rate ratio): inverse probability of treatment weighting, standardized mortality ratio (SMR)-treated, SMR-untreated, the average treatment effect in the overlap population (ATO), matching, and entropy. With no unmeasured confounding, the ATO (123%) and "Crump" trimming (112%) improved relative efficiency compared with untrimmed inverse probability of treatment weighting. With unmeasured confounding, untrimmed estimates were biased irrespective of weighting method, and only Stürmer and Walker trimming consistently reduced bias. In settings where unmeasured confounding (e.g., frailty) may lead physicians to withhold treatment, Stürmer and Walker trimming should be considered before primary analysis.
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