Evidence map›Paper›PMID 33615280›Full record

ArticleBrain, behavior, & immunity - health2020

Self-reported cannabis use and biomarkers of inflammation among adults in the United States.

Chukwuemeka N Okafor, Michael Li, Jason Paltzer

Open access · goldAbstract read
In one paragraph

Article in Brain, behavior, & immunity - health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
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  10. Social Genomics of Methamphetamine Use, HIV Viral Load, and Social Adversity.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2022
    Article
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  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Chukwuemeka N OkaforDepartment of Public Health, Robbins College of Health and Human Sciences, Baylor University, One Bear Place #97343, Waco, TX, 76798, USA.
Michael LiDepartment of Family Medicine, David Geffen School of Medicine, University of California, 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA.
Jason PaltzerDepartment of Public Health, Robbins College of Health and Human Sciences, Baylor University, One Bear Place #97343, Waco, TX, 76798, USA.
Baylor University · USUniversity of California, Los Angeles · US

Funding

UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Sung-Jae Lee · 1997 to 2026
$53.5M
MSM and Substances Cohort at UCLA Linking Infections Noting Effects (MASCULINE) U01DA036267 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GORBACH, PAMINA MAE, SHOPTAW, STEVEN J · 2013 to 2024
$20.5M
Postdoctoral Training in Global AIDS Prevention ResearchT32MH080634 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JESSE LAWTON CLARK, Pamina Mae Gorbach · 2007 to 2026
$6.4M
The impact of cannabinoids on inflammation, HIV viral load and symptoms of distress among persons living with HIVK01DA047912 · NIDA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI OKAFOR, CHUKWUEMEKA NKEMAKONAM · 2019 to 2023
$682k
NIDA NIH HHS K01 DA047912NIDA NIH HHS U01 DA036267NIMH NIH HHS P30 MH058107NIMH NIH HHS T32 MH080634
6 · The paper itself

Abstract

backgroundCannabis is among the most frequently used substance in United States (U.S.). Studies evaluating the association between cannabis use and inflammation in humans have been few and have not explored potential sex-dependent effects.

objectiveTo examine the relationship between self-reported cannabis use and high-sensitivity C-reactive protein (hsCRP), Interleukin 6 (IL-6) and fibrinogen.

methodsWe used Wave 1 of the Population Assessment of Tobacco and Health (PATH) - a nationally representative sample of adults in the U.S. Weighted linear regression models were used to determine associations of self-reported cannabis use with natural log-transformed hs-CRP, IL-6 and fibrinogen adjusting for sociodemographic and psychosocial factors.

resultsSelf-reported cannabis use, particularly cannabis use within the past 30 days, was associated with lower levels of each biomarker of systemic inflammation, although findings were imprecise. Specifically, in multivariable models, the associations between respondents who self-reported cannabis use in the past 30 days compared to never use was imprecise for hs-CRP (β= -0.15, 95% confidence interval (CI): -0.32, 0.00), IL-6 (β= - 0.02, 95% CI: -0.10, 0.05) and fibrinogen (β= - 0.01, 95% CI: -0.04, 0.02). We did not find that these associations differed significantly by sex. DISCUSSIONS: Data from this nationally representative study suggest potential anti-inflammatory effects of recent cannabis use. Additional studies that biologically measure the THC and CBD concentrations of the cannabis used and employ prospective and or experimental study designs investigate cannabis and inflammation associations are needed.

Indexed as

adultsCannabisinflammation

Identifiers

PMID33615280
PMCPMC7894624
OpenAlexW3044384448

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.