Evidence map›Paper›PMID 33615185›Full record

ArticleACS pharmacology & translational science2021

Wound Healing Activity of a Novel Formulation SKRIN via Induction of Cell Cycle Progression and Inhibition of PCNA-p21 Complex Interaction Leading to Cell Survival and Proliferation.

Swatantra Kumar, Vimal K Maurya, Sai V Chitti, Russell Kabir, Karuna Shanker, Debadatta Nayak, Anil Khurana, Raj K Manchanda, Srinivasulu Gadugu, Vijay Kumar and 1 more

Open access · greenAbstract read
In one paragraph

Article in ACS pharmacology & translational science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Swatantra KumarCentre for Advanced Research (CFAR), Faculty of Medicine, King George's Medical University (KGMU), Lucknow 226003, India.
Vimal K MauryaCentre for Advanced Research (CFAR), Faculty of Medicine, King George's Medical University (KGMU), Lucknow 226003, India.
Sai V ChittiCSIR-Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India.
Russell KabirSchool of Allied Health, Faculty of Health, Education, Medicine, and Social Care, Anglia Ruskin University, Chelmsford CM1 1SQ, United Kingdom.
Karuna ShankerCSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India.
Debadatta NayakMinistry of Ayush, CCRH, Janakpuri, New Delhi 110058, India.
Anil KhuranaMinistry of Ayush, CCRH, Janakpuri, New Delhi 110058, India.
Raj K ManchandaMinistry of Ayush, CCRH, Janakpuri, New Delhi 110058, India.
Srinivasulu GaduguDepartment of Medicine, JSPS Government Medical College, Hyderabad 500013, India.
Vijay KumarDepartment of Plastic Surgery, King George's Medical University (KGMU), Lucknow 226003, India.
Shailendra K SaxenaCentre for Advanced Research (CFAR), Faculty of Medicine, King George's Medical University (KGMU), Lucknow 226003, India.
King George's Medical University · INMinistry of AYUSH · INCentre for Cellular and Molecular Biology · INAnglia Ruskin University · GBCentral Institute of Medicinal and Aromatic Plants · INGovernment Medical College · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The process of wound healing is a dynamic event that starts with inflammation, proliferation, and cell migration of various types of fibroblast cells. Therefore, identification of potential molecules which may increase the wound healing capacity of fibroblast cells is crucial. A novel hydroalcoholic formulation of belladonna (SKRIN), was developed and characterized by GC-MS/MS, DLS, TEM, and AFM and was found to contain atropine and scopolamine exhibit in aggregated nanosized particles. SKRIN-mediated fibroblast cell survival was elucidated in the presence of H

Identifiers

PMID33615185
PMCPMC7887853
OpenAlexW3119571587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.