Evidence map›Paper›PMID 33615152›Full record

ArticleFASEB bioAdvances2021

Human-specific polymorphic pseudogenization of

Shoib S Siddiqui, Michael Vaill, Raymond Do, Naazneen Khan, Andrea L Verhagen, Wu Zhang, Heinz-Josef Lenz, Teresa L Johnson-Pais, Robin J Leach, Gary Fraser and 4 more

Open access · goldAbstract read
In one paragraph

Article in FASEB bioAdvances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Siglecs: From Biomodulation to Immunotherapy.Current protein & peptide science · 2026
    Review
  3. Article
  4. Tumor-expressed GPNMB orchestrates Siglec-9Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. The Role of Glycans in Human Immunity-A Sweet Code.Molecules (Basel, Switzerland) · 2025
    Review
  6. Article
  7. Analysis ofHeliyon · 2024
    Article
  8. Review
  9. Review
  10. Gangliosides as Siglec ligands.Glycoconjugate journal · 2023
    Review
  11. Review
  12. Article
  13. Review
  14. Siglec Ligands.Cells · 2021
    Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Shoib S SiddiquiDepartments of Medicine, Cellular and Molecular Medicine, and Pathology, Glycobiology Research and Training Cente and Center for Academic Research and Training in Anthropogeny University of California San Diego CA USA.ORCID https://orcid.org/0000-0002-7028-290X
Michael VaillDepartments of Medicine, Cellular and Molecular Medicine, and Pathology, Glycobiology Research and Training Cente and Center for Academic Research and Training in Anthropogeny University of California San Diego CA USA.ORCID https://orcid.org/0000-0002-4714-9254
Raymond DoDepartments of Medicine, Cellular and Molecular Medicine, and Pathology, Glycobiology Research and Training Cente and Center for Academic Research and Training in Anthropogeny University of California San Diego CA USA.ORCID https://orcid.org/0000-0003-0984-2696
Naazneen KhanDepartments of Medicine, Cellular and Molecular Medicine, and Pathology, Glycobiology Research and Training Cente and Center for Academic Research and Training in Anthropogeny University of California San Diego CA USA.ORCID https://orcid.org/0000-0002-4386-1703
Andrea L VerhagenDepartments of Medicine, Cellular and Molecular Medicine, and Pathology, Glycobiology Research and Training Cente and Center for Academic Research and Training in Anthropogeny University of California San Diego CA USA.ORCID https://orcid.org/0000-0002-0535-4006
Wu ZhangUniversity of Southern California Norris Comprehensive Cancer Center Los Angeles CA USA.ORCID https://orcid.org/0000-0001-5477-9679
Heinz-Josef LenzUniversity of Southern California Norris Comprehensive Cancer Center Los Angeles CA USA.ORCID https://orcid.org/0000-0003-2178-9568
Teresa L Johnson-PaisDepartment of Urology University of TX Health Science Center San Antonio TX USA.ORCID https://orcid.org/0000-0001-7580-1206
Robin J LeachDepartment of Urology University of TX Health Science Center San Antonio TX USA.ORCID https://orcid.org/0000-0002-3201-5579
Gary FraserSchool of Public Health Loma Linda University Loma Linda CA USA.ORCID https://orcid.org/0000-0002-5577-3524
Charles WangSchool of Public Health Loma Linda University Loma Linda CA USA.ORCID https://orcid.org/0000-0001-8861-2121
Gen-Sheng FengDepartments of Medicine, Cellular and Molecular Medicine, and Pathology, Glycobiology Research and Training Cente and Center for Academic Research and Training in Anthropogeny University of California San Diego CA USA.ORCID https://orcid.org/0000-0003-1255-4708
Nissi VarkiDepartments of Medicine, Cellular and Molecular Medicine, and Pathology, Glycobiology Research and Training Cente and Center for Academic Research and Training in Anthropogeny University of California San Diego CA USA.ORCID https://orcid.org/0000-0001-9839-1254
Ajit VarkiDepartments of Medicine, Cellular and Molecular Medicine, and Pathology, Glycobiology Research and Training Cente and Center for Academic Research and Training in Anthropogeny University of California San Diego CA USA.ORCID https://orcid.org/0000-0002-2206-975X
University of California San Diego · USLoma Linda University · USThe University of Texas Health Science Center at San Antonio · USUniversity of Southern California · US

Funding

SAN ANTONIO CENTER OF BIOMARKERS OF RISK FOR PROSTATE CAU01CA086402 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LEACH, ROBIN JEAN, THOMPSON, IAN M. · 2000 to 2018
$33.1M
Training Program in Basic Clinical GeneticsT32GM008666 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, BRUCE A · 1998 to 2021
$8.6M
Training Grant in GastroenterologyT32DK007202 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA · 1985 to 2022
$7.7M
BIOSYNTHESIS AND REGULATION OF SUBSTITUTED SIALIC ACIDSR01GM032373 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI VARKI, AJIT P · 1985 to 2022
$6.9M
NCI NIH HHS U01 CA086402NIDDK NIH HHS T32 DK007202NIGMS NIH HHS R01 GM032373NIGMS NIH HHS T32 GM008666
6 · The paper itself

Abstract

Compared with our closest living evolutionary cousins, humans appear unusually prone to develop carcinomas (cancers arising from epithelia). The

Indexed as

advanced carcinomadot blotimmunohistochemistrypseudogenizationSIGLEC12

Identifiers

PMID33615152
PMCPMC7876704
OpenAlexW3112771588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.